Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists
Author(s)
Spell, Sarah R
Mangrum, John B
Peterson, Erica J
Fabris, Daniele
Ptak, Roger
Farrell, Nicholas P
Griffith University Author(s)
Year published
2017
Metadata
Show full item recordAbstract
The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.
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Journal Title
Chemical Communications
Volume
53
Issue
1
Subject
Chemical sciences