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  • Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

    Author(s)
    Spell, Sarah R
    Mangrum, John B
    Peterson, Erica J
    Fabris, Daniele
    Ptak, Roger
    Farrell, Nicholas P
    Griffith University Author(s)
    Farrell, Nicholas
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.
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    Journal Title
    Chemical Communications
    Volume
    53
    Issue
    1
    DOI
    https://doi.org/10.1039/c6cc07970a
    Subject
    Chemical sciences
    Publication URI
    http://hdl.handle.net/10072/407725
    Collection
    • Journal articles

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