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dc.contributor.authorShokoohmand, Ali
dc.contributor.authorJeon, June E
dc.contributor.authorTheodoropoulos, Christina
dc.contributor.authorBaldwin, Jeremy G
dc.contributor.authorHutmacher, Dietmar W
dc.contributor.authorFeigl, Beatrix
dc.date.accessioned2021-09-08T23:04:44Z
dc.date.available2021-09-08T23:04:44Z
dc.date.issued2017
dc.identifier.issn1616-5187
dc.identifier.doi10.1002/mabi.201700221
dc.identifier.urihttp://hdl.handle.net/10072/407773
dc.description.abstractVarious in vitro culture systems have been used to investigate the pathogenesis of age-related macular degeneration (AMD). However, many still rely on oversimplified monolayer culture models. AMD is a complex disease, associated with the pathological changes to multiple structural components such as the Bruch's membrane, retinal pigment epithelium (RPE), and choroidal endothelial cells. This study aims to construct a novel 3D coculture model using the polycaprolactone (PCL)-gelatin electrospun scaffold, with human RPE cells (hRPE) and primate choroidal cells (RF-6A). Results from this study show that PCL-gelatin scaffolds have a highly porous ultrastructure that supports the attachment, proliferation, differentiation, and migration of the hRPEs and choroidal endothelial cells. It is also demonstrated that the PCL-gelatin 3D coculture model may be useful in exploring the molecular interplay between the hPRE and the choroidal endothelial cells, and their effects on growth factor modulation, which may be important in the pathogenesis of AMD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofissue12
dc.relation.ispartofjournalMacromolecular Bioscience
dc.relation.ispartofvolume17
dc.subject.fieldofresearchMacromolecular and materials chemistry
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchChemical engineering
dc.subject.fieldofresearchcode3403
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4004
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsTechnology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsBiochemistry & Molecular Biology
dc.titleA Novel 3D Cultured Model for Studying Early Changes in Age-Related Macular Degeneration
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationShokoohmand, A; Jeon, JE; Theodoropoulos, C; Baldwin, JG; Hutmacher, DW; Feigl, B, A Novel 3D Cultured Model for Studying Early Changes in Age-Related Macular Degeneration, Macromolecular Bioscience, 2017, 17 (12)
dc.date.updated2021-09-08T23:02:21Z
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.
gro.griffith.authorShokoohmand, Ali


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