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dc.contributor.authorGurumoorthy, Perumal
dc.contributor.authorMahendiran, Dharmasivam
dc.contributor.authorRahiman, Aziz Kalilur
dc.date.accessioned2021-09-08T23:27:52Z
dc.date.available2021-09-08T23:27:52Z
dc.date.issued2016
dc.identifier.issn0009-2797
dc.identifier.doi10.1016/j.cbi.2016.02.002
dc.identifier.urihttp://hdl.handle.net/10072/407786
dc.description.abstractEight water soluble mixed-ligand nickel(II) complexes of the type [NiL1–4(diimine)H2O]·(ClO4)2, (1–8) where L1−4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, and diimine = 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen) were synthesized and characterized by elemental analysis and spectroscopic methods. The uncoordinated perchlorate anions was ascertained form IR spectra of the complexes, and the absorption spectra reveal the octahedron geometry around nickel(II) ion with tridentate Schiff base ligand, diimine and a coordinated water molecule. Cyclic voltammograms of the complexes indicate the one-electron irreversible processes in the cathodic and anodic region. In vitro antioxidant activity proved the significant radical scavenging activity of the complexes against DPPH radical. The groove/electrostatic binding nature of complexes with CT–DNA (calf thymus deoxyribonucleic acid) were affirmed by absorption, hydrodynamic and voltammetric titration experiments and docking analysis. All the complexes exhibit significant cleavage activity on plasmid DNA via hydrolytic and oxidatively, in which the oxidative mechanism involves hydroxyl radicals and supports the possibility of minor-groove binding. The complex 4 shows significant topoisomerase I (Topo-I) inhibitory activity. The molecular modeling analysis of complexes with phosphatidylinositol-3-kinase (PI3K) receptor indicate the hydrogen bonding with Met1039, Asp837 and Leu1027, and hydrophobic interactions with Ser488, Asn498, Asp500, Gln662, Lys668, Ile844, Ile847, Ile850, Val941, Leu942, Leu1020, Met1034, Leu1035, Thr1037, Met1039, Gln1041 and Ile1051 of subdomain IIA of BSA. The complexes show σ–π interaction between diimines and amino groups of Leu1030 and Arg839.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom21
dc.relation.ispartofpageto35
dc.relation.ispartofjournalChemico-Biological Interactions
dc.relation.ispartofvolume248
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsPharmacology & Pharmacy
dc.subject.keywordsToxicology
dc.titleTheoretical calculations, DNA interaction, topoisomerase I and phosphatidylinositol-3-kinase studies of water soluble mixed-ligand nickel(II) complexes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGurumoorthy, P; Mahendiran, D; Rahiman, AK, Theoretical calculations, DNA interaction, topoisomerase I and phosphatidylinositol-3-kinase studies of water soluble mixed-ligand nickel(II) complexes, Chemico-Biological Interactions, 2016, 248, pp. 21-35
dcterms.dateAccepted2016-02-07
dc.date.updated2021-09-08T23:25:40Z
gro.hasfulltextNo Full Text
gro.griffith.authorDharmasivam, Mahendiran


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