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  • Effects of magnetic field strength and particle aggregation on relaxivity of ultra-small dual contrast iron oxide nanoparticles

    Author(s)
    Ta, Hang T
    Li, Zhen
    Wu, Yuao
    Cowin, Gary
    Zhang, Shaohua
    Yago, Anya
    Whittaker, Andrew K
    Xu, Zhi Ping
    Griffith University Author(s)
    Ta, Hang
    Wu, Yuao
    Year published
    2017
    Metadata
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    Abstract
    This study aims to compare the relaxivities of ultra-small dual positive and negative contrast iron oxide nanoparticles (DCION) at different magnetic field strengths ranging from 4.7 to 16.4 T at physiological temperatures; and to investigate the effect of particle aggregation on relaxivities. Relaxivities of DCIONs were determined by magnetic resonance imaging scanners at 4.7, 7, 9.4, and 16.4 T. Both longitudinal (T 1) and transverse relaxation times (T 2) were measured by appropriate spin-echo sequences. It has been found that both longitudinal and transverse relaxivities are significantly dependent on the magnetic field ...
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    This study aims to compare the relaxivities of ultra-small dual positive and negative contrast iron oxide nanoparticles (DCION) at different magnetic field strengths ranging from 4.7 to 16.4 T at physiological temperatures; and to investigate the effect of particle aggregation on relaxivities. Relaxivities of DCIONs were determined by magnetic resonance imaging scanners at 4.7, 7, 9.4, and 16.4 T. Both longitudinal (T 1) and transverse relaxation times (T 2) were measured by appropriate spin-echo sequences. It has been found that both longitudinal and transverse relaxivities are significantly dependent on the magnetic field strength. Particle aggregation also strongly affects the relaxivities. Awareness of the field strength and particle colloid stability is crucial for the comparison and evaluation of relaxivity values of these ultra-small iron oxide nanoparticles, and also for their medical applications as contrast agents.
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    Journal Title
    Materials Research Express
    Volume
    4
    Issue
    11
    DOI
    https://doi.org/10.1088/2053-1591/aa96e3
    Subject
    Materials engineering
    Science & Technology
    Technology
    Materials Science, Multidisciplinary
    Materials Science
    dual contrast iron oxide nanoparticle
    Publication URI
    http://hdl.handle.net/10072/407806
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    • Journal articles

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