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  • Loop-Mediated Isothermal Amplification in a Core-Shell Bead Assay for the Detection of Tyrosine Kinase AXL Overexpression

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    Umer506939-Published.pdf (2.123Mb)
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    Version of Record (VoR)
    Author(s)
    Sreejith, Kamalalayam Rajan
    Umer, Muhammad
    Singha, Pradip
    Nguyen, Nhat-Khuong
    Kasetsirikul, Surasak
    Ooi, Chin Hong
    Shiddiky, Muhammad JA
    Nguyen, Nam-Trung
    Griffith University Author(s)
    Umer, Muhammad
    Ooi, Chin Hong
    Singha, Pradip
    Nguyen, Nam-Trung
    Shiddiky, Muhammad J.
    Kasetsirikul, Surasak
    Nguyen, Nhat Khuong
    Kamalalayam Rajan, Sreejith
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    The upregulated expression of tyrosine kinase AXL has been reported in several hema-tologic and solid human tumors, including gastric, breast, colorectal, prostate and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first ever loop-mediated isothermal amplification (LAMP) in a core-shell bead assay for the detection of AXL gene overexpression. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first ever use of core-shell beads as a microreactor to perform LAMP as an attempt to ...
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    The upregulated expression of tyrosine kinase AXL has been reported in several hema-tologic and solid human tumors, including gastric, breast, colorectal, prostate and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first ever loop-mediated isothermal amplification (LAMP) in a core-shell bead assay for the detection of AXL gene overexpression. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally-friendly laboratory practices.
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    Journal Title
    Micromachines
    Volume
    12
    Issue
    8
    DOI
    https://doi.org/10.3390/mi12080905
    Copyright Statement
    © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Nanotechnology
    Science & Technology
    Physical Sciences
    Chemistry, Analytical
    Nanoscience
    Publication URI
    http://hdl.handle.net/10072/407845
    Collection
    • Journal articles

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