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dc.contributor.authorSreejith, Kamalalayam Rajan
dc.contributor.authorUmer, Muhammad
dc.contributor.authorSingha, Pradip
dc.contributor.authorNguyen, Nhat-Khuong
dc.contributor.authorKasetsirikul, Surasak
dc.contributor.authorOoi, Chin Hong
dc.contributor.authorShiddiky, Muhammad JA
dc.contributor.authorNguyen, Nam-Trung
dc.date.accessioned2021-09-09T04:11:19Z
dc.date.available2021-09-09T04:11:19Z
dc.date.issued2021
dc.identifier.issn2072-666X
dc.identifier.doi10.3390/mi12080905
dc.identifier.urihttp://hdl.handle.net/10072/407845
dc.description.abstractThe upregulated expression of tyrosine kinase AXL has been reported in several hema-tologic and solid human tumors, including gastric, breast, colorectal, prostate and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first ever loop-mediated isothermal amplification (LAMP) in a core-shell bead assay for the detection of AXL gene overexpression. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally-friendly laboratory practices.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofissue8
dc.relation.ispartofjournalMicromachines
dc.relation.ispartofvolume12
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchMicrofluidics and nanofluidics
dc.subject.fieldofresearchcode4018
dc.subject.fieldofresearchcode401210
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsChemistry, Analytical
dc.subject.keywordsNanoscience
dc.titleLoop-Mediated Isothermal Amplification in a Core-Shell Bead Assay for the Detection of Tyrosine Kinase AXL Overexpression
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSreejith, KR; Umer, M; Singha, P; Nguyen, N-K; Kasetsirikul, S; Ooi, CH; Shiddiky, MJA; Nguyen, N-T, Loop-Mediated Isothermal Amplification in a Core-Shell Bead Assay for the Detection of Tyrosine Kinase AXL Overexpression, Micromachines, 2021, 12 (8)
dcterms.dateAccepted2021-07-27
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-09-09T01:40:40Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorUmer, Muhammad
gro.griffith.authorOoi, Chin Hong
gro.griffith.authorNguyen, Nam-Trung
gro.griffith.authorShiddiky, Muhammad J.
gro.griffith.authorKamalalayam Rajan, Sreejith


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