dc.contributor.author | Sreejith, Kamalalayam Rajan | |
dc.contributor.author | Umer, Muhammad | |
dc.contributor.author | Singha, Pradip | |
dc.contributor.author | Nguyen, Nhat-Khuong | |
dc.contributor.author | Kasetsirikul, Surasak | |
dc.contributor.author | Ooi, Chin Hong | |
dc.contributor.author | Shiddiky, Muhammad JA | |
dc.contributor.author | Nguyen, Nam-Trung | |
dc.date.accessioned | 2021-09-09T04:11:19Z | |
dc.date.available | 2021-09-09T04:11:19Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2072-666X | |
dc.identifier.doi | 10.3390/mi12080905 | |
dc.identifier.uri | http://hdl.handle.net/10072/407845 | |
dc.description.abstract | The upregulated expression of tyrosine kinase AXL has been reported in several hema-tologic and solid human tumors, including gastric, breast, colorectal, prostate and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first ever loop-mediated isothermal amplification (LAMP) in a core-shell bead assay for the detection of AXL gene overexpression. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally-friendly laboratory practices. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | MDPI | |
dc.relation.ispartofissue | 8 | |
dc.relation.ispartofjournal | Micromachines | |
dc.relation.ispartofvolume | 12 | |
dc.subject.fieldofresearch | Nanotechnology | |
dc.subject.fieldofresearch | Microfluidics and nanofluidics | |
dc.subject.fieldofresearchcode | 4018 | |
dc.subject.fieldofresearchcode | 401210 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Physical Sciences | |
dc.subject.keywords | Chemistry, Analytical | |
dc.subject.keywords | Nanoscience | |
dc.title | Loop-Mediated Isothermal Amplification in a Core-Shell Bead Assay for the Detection of Tyrosine Kinase AXL Overexpression | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Sreejith, KR; Umer, M; Singha, P; Nguyen, N-K; Kasetsirikul, S; Ooi, CH; Shiddiky, MJA; Nguyen, N-T, Loop-Mediated Isothermal Amplification in a Core-Shell Bead Assay for the Detection of Tyrosine Kinase AXL Overexpression, Micromachines, 2021, 12 (8) | |
dcterms.dateAccepted | 2021-07-27 | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2021-09-09T01:40:40Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Umer, Muhammad | |
gro.griffith.author | Ooi, Chin Hong | |
gro.griffith.author | Nguyen, Nam-Trung | |
gro.griffith.author | Shiddiky, Muhammad J. | |
gro.griffith.author | Kamalalayam Rajan, Sreejith | |