dc.contributor.author | Poulsen, SA | |
dc.contributor.author | Young, DJ | |
dc.contributor.author | Quinn, RJ | |
dc.contributor.editor | Prof D.L. Boger | |
dc.date.accessioned | 2017-05-03T13:30:21Z | |
dc.date.available | 2017-05-03T13:30:21Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.doi | 10.1016/S0960-894X(00)00620-X | |
dc.identifier.uri | http://hdl.handle.net/10072/4078 | |
dc.description.abstract | The synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines has been performed by aromatic nucleophilic substitution of 4-amino-6-chloro-1-phenylpyrazolo[3,4-d]pyrimidine under conditions of high pressure at ambient temperature. Conventional synthetic conditions (reflux at atmospheric pressure) were unsuccessful. The S enantiomer 11 displayed higher affinity and selectivity for the adenosine A1 receptor than the R enantiomer 12. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Pergamon | |
dc.publisher.place | UK | |
dc.relation.ispartofpagefrom | 191 | |
dc.relation.ispartofpageto | 193 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Bioorganic & Medicinal Chemistry Letters | |
dc.relation.ispartofvolume | 11 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearch | History, heritage and archaeology | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.fieldofresearchcode | 43 | |
dc.title | High-Pressure Synthesis of Enantiomerically Pure C-6 Substituted Pyrazolo[3,4-d]pyrimidines | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2015-05-04T01:46:27Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Quinn, Ronald J. | |
gro.griffith.author | Poulsen, Sally-Ann | |