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dc.contributor.authorPoulsen, SA
dc.contributor.authorYoung, DJ
dc.contributor.authorQuinn, RJ
dc.contributor.editorProf D.L. Boger
dc.date.accessioned2017-05-03T13:30:21Z
dc.date.available2017-05-03T13:30:21Z
dc.date.issued2001
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/S0960-894X(00)00620-X
dc.identifier.urihttp://hdl.handle.net/10072/4078
dc.description.abstractThe synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines has been performed by aromatic nucleophilic substitution of 4-amino-6-chloro-1-phenylpyrazolo[3,4-d]pyrimidine under conditions of high pressure at ambient temperature. Conventional synthetic conditions (reflux at atmospheric pressure) were unsuccessful. The S enantiomer 11 displayed higher affinity and selectivity for the adenosine A1 receptor than the R enantiomer 12.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.publisher.placeUK
dc.relation.ispartofpagefrom191
dc.relation.ispartofpageto193
dc.relation.ispartofissue2
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume11
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchHistory, heritage and archaeology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode43
dc.titleHigh-Pressure Synthesis of Enantiomerically Pure C-6 Substituted Pyrazolo[3,4-d]pyrimidines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-04T01:46:27Z
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorPoulsen, Sally-Ann


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