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  • WormJam: A consensusC. elegansMetabolic Reconstruction and Metabolomics Community and Workshop Series

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    Schirra512111-Published.pdf (1.128Mb)
    Author(s)
    Hastings, Janna
    Mains, Abraham
    Artal-Sanz, Marta
    Bergmann, Sven
    Braeckman, Bart P
    Bundy, Jake
    Cabreiro, Filipe
    Dobson, Paul
    Ebert, Paul
    Hattwell, Jake
    Hefzi, Hooman
    Houtkooper, Riekelt H
    Jelier, Rob
    Schirra, Horst Joachim
    et al.
    Griffith University Author(s)
    Schirra, Horst Joachim
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    A GENiE (EU COST action, www.worm-genie.eu) workshop was held at the Babraham Institute in Cambridge, UK on April 19 and 20, 2017, to discuss global challenges around Caenorhabditis elegans metabolic reconstructions and metabolomics (http://www.babraham.ac.uk/genie-workshop). This short report describes the outcomes from that workshop, notably the initiation of a global community to collaboratively discover and describe the metabolism of C. elegans. C. elegans is a well established workhorse for research in both fundamental biology and medicine, with applications including developmental biology, ageing-associated research ...
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    A GENiE (EU COST action, www.worm-genie.eu) workshop was held at the Babraham Institute in Cambridge, UK on April 19 and 20, 2017, to discuss global challenges around Caenorhabditis elegans metabolic reconstructions and metabolomics (http://www.babraham.ac.uk/genie-workshop). This short report describes the outcomes from that workshop, notably the initiation of a global community to collaboratively discover and describe the metabolism of C. elegans. C. elegans is a well established workhorse for research in both fundamental biology and medicine, with applications including developmental biology, ageing-associated research and the elucidation of pathomechanisms of diseases.1Corsi AK, Wightman B, Chalfie M. A transparent window into biology: A primer on Caenorhabditis elegans. Genetics. 2015;200(2):387-407. doi:10.1534/genetics.115.176099. PMID:26088431 [Crossref], [PubMed], [Web of Science ®], [Google Scholar] Powerful molecular as well as genetic tools, ease of cultivation, short generation times and a considerable overlap in its fundamental biology with higher organisms, make C. elegans an ideal object of study. In recent years, metabolism is increasingly recognised as an important contributor to C. elegans healthspan and lifespan, as well as the basis of adaptation to different environments.2,3 Most of the historical efforts to detect changes in metabolism have been based on molecular tools including gene expression and/or reporter strains. Despite its importance for a large number of research applications, efforts to reconstruct the global map of C. elegans metabolism only started recently, notably with the publication of two independent constraint-based metabolic models last year4,5 (although automated reconstructions from pathway databases were produced before.6) Such whole-genome metabolic reconstructions are a key ingredient for a large number of applications including the integration of diverse -omics datasets, investigation of disease-associated changes in metabolism, studying the responses to nutritional interventions, identifying gene-environment interactions, and elucidating inter-organismal interactions on the metabolic level at both physiological and evolutionary timescales.7 The reconstruction of C. elegans metabolism thus promises to open up the extensive toolbox of constraint-based modelling for C. elegans research.
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    Journal Title
    Worm
    Volume
    6
    Issue
    2
    DOI
    https://doi.org/10.1080/21624054.2017.1373939
    Copyright Statement
    © 2017 The Author(s). Published with license by Taylor & Francis© Janna Hastings, Abraham Mains, Marta Artal-Sanz, Sven Bergmann, Bart P. Braeckman, Jake Bundy, Filipe Cabreiro, Paul Dobson, Paul Ebert, Jake Hattwell, Hooman Hefzi, Riekelt H. Houtkooper, Rob Jelier, Chintan Joshi, Varun B. Kothamachu, Nathan Lewis, Artur Bastos Lourençco, Yu Nie, Povilas Norvaisas, Juliette Pearce, Cristian Riccio, Nicolas Rodriguez, Toon Santermans, Pasquale Scarcia, Horst Joachim Schirra, Ming Sheng, Reuben Smith, Manusnan Suriyalaksh, Benjamin Towbin, Mary Ann Tuli, Michel van Weeghel, David Weinkove, Aleksandra Zecic, Johannes Zimmermann, Nicolas le Novère, Christoph Kaleta, Michael Witting, and Olivia Casanueva This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Publication URI
    http://hdl.handle.net/10072/407911
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