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  • MicroRNAs in the skin: Role in development, homoeostasis and regeneration

    Author(s)
    Horsburgh, Steven
    Fullard, Nicola
    Roger, Mathilde
    Degnan, Abbie
    Todryk, Stephen
    Przyborski, Stefan
    O'Reilly, Steven
    Griffith University Author(s)
    Todryk, Stephen M.
    Year published
    2017
    Metadata
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    Abstract
    The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each, a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability to regulate gene expression via post-transcriptional gene silencing. Of interest, is that a plethora of data demonstrates that a number of ...
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    The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each, a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability to regulate gene expression via post-transcriptional gene silencing. Of interest, is that a plethora of data demonstrates that a number of miRs are highly expressed within the skin, and are evidently key regulators of numerous vital processes to maintain non-aberrant functioning. Recently, miRs have been targeted as therapeutic interventions due to the ability of synthetic 'antagomiRs' to down-regulate abnormal miR expression, thereby potentiating wound healing and attenuating fibrotic processes which can contribute to disease such as systemic sclerosis (SSc). This review will provide an introduction to the structure and function of the skin and miR biogenesis, before summarizing the literature pertaining to the role of miRs. Finally, miR therapies will also be discussed, highlighting important future areas of research.
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    Journal Title
    Clinical Science
    Volume
    131
    Issue
    15
    DOI
    https://doi.org/10.1042/CS20170039
    Subject
    Biomedical and clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Research & Experimental Medicine
    GROWTH-FACTOR EXPRESSION
    Publication URI
    http://hdl.handle.net/10072/408012
    Collection
    • Journal articles

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