Role of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: Where are we now?
Author(s)
Rudd, Penny A
Thomas, Belinda J
Zaid, Ali
MacDonald, Martin
Kan-o, Keiko
Rolph, Michael S
Soorneedi, Anand R
Bardin, Philip G
Mahalingam, Suresh
Year published
2017
Metadata
Show full item recordAbstract
Since its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive ...
View more >Since its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive responses. In this review, we discuss the prevalence of hMPV infection in pediatric and adult populations and its potential role in asthma exacerbation. We also review recent advances made in animalmodels to determine immune responses following hMPV infection, and compare to what is known about RSV.
View less >
View more >Since its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive responses. In this review, we discuss the prevalence of hMPV infection in pediatric and adult populations and its potential role in asthma exacerbation. We also review recent advances made in animalmodels to determine immune responses following hMPV infection, and compare to what is known about RSV.
View less >
Journal Title
Clinical Science
Volume
131
Issue
14
Funder(s)
NHMRC
Grant identifier(s)
APP1047250
Subject
Biomedical and clinical sciences
Health sciences
Science & Technology
Life Sciences & Biomedicine
Research & Experimental Medicine
OBSTRUCTIVE PULMONARY-DISEASE