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  • Role of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: Where are we now?

    Author(s)
    Rudd, Penny A
    Thomas, Belinda J
    Zaid, Ali
    MacDonald, Martin
    Kan-o, Keiko
    Rolph, Michael S
    Soorneedi, Anand R
    Bardin, Philip G
    Mahalingam, Suresh
    Griffith University Author(s)
    Mahalingam, Suresh
    Rolph, Michael S.
    Rudd, Penny A.
    Zaid, Ali
    Soorneedi, Anand
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Since its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive ...
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    Since its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive responses. In this review, we discuss the prevalence of hMPV infection in pediatric and adult populations and its potential role in asthma exacerbation. We also review recent advances made in animalmodels to determine immune responses following hMPV infection, and compare to what is known about RSV.
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    Journal Title
    Clinical Science
    Volume
    131
    Issue
    14
    DOI
    https://doi.org/10.1042/CS20160011
    Subject
    Biomedical and clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Research & Experimental Medicine
    OBSTRUCTIVE PULMONARY-DISEASE
    Publication URI
    http://hdl.handle.net/10072/408013
    Collection
    • Journal articles

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