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dc.contributor.authorRudd, Penny A
dc.contributor.authorThomas, Belinda J
dc.contributor.authorZaid, Ali
dc.contributor.authorMacDonald, Martin
dc.contributor.authorKan-o, Keiko
dc.contributor.authorRolph, Michael S
dc.contributor.authorSoorneedi, Anand R
dc.contributor.authorBardin, Philip G
dc.contributor.authorMahalingam, Suresh
dc.description.abstractSince its discovery in 2001, human metapneumovirus (hMPV) has been identified as an important cause of respiratory tract infection in young children, second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive responses. In this review, we discuss the prevalence of hMPV infection in pediatric and adult populations and its potential role in asthma exacerbation. We also review recent advances made in animalmodels to determine immune responses following hMPV infection, and compare to what is known about RSV.
dc.publisherPortland Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofjournalClinical Science
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsResearch & Experimental Medicine
dc.titleRole of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: Where are we now?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRudd, PA; Thomas, BJ; Zaid, A; MacDonald, M; Kan-o, K; Rolph, MS; Soorneedi, AR; Bardin, PG; Mahalingam, S, Role of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: Where are we now?, Clinical Science, 2017, 131 (14), pp. 1713-1721
gro.hasfulltextNo Full Text
gro.griffith.authorMahalingam, Suresh
gro.griffith.authorRolph, Michael S.
gro.griffith.authorRudd, Penny A.
gro.griffith.authorZaid, Ali
gro.griffith.authorSoorneedi, Anand

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