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dc.contributor.authorReye, Gina
dc.contributor.authorHuang, Xuan
dc.contributor.authorHaupt, Larisa M
dc.contributor.authorMurphy, Ryan J
dc.contributor.authorNorthey, Jason J
dc.contributor.authorThompson, Erik W
dc.contributor.authorMomot, Konstantin I
dc.contributor.authorHugo, Honor J
dc.date.accessioned2021-09-16T04:07:13Z
dc.date.available2021-09-16T04:07:13Z
dc.date.issued2021
dc.identifier.issn1083-3021en_US
dc.identifier.doi10.1007/s10911-021-09494-3en_US
dc.identifier.urihttp://hdl.handle.net/10072/408063
dc.description.abstractRegions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned collagen fibrils to control tissue stiffness and hence the response to mechanical forces. Literature is accumulating to support the notion that mechanical stiffness may drive PG synthesis in the breast contributing to MD. We review emerging patterns in MD and other biological settings, of a positive feedback cycle of force promoting PG synthesis, such as in articular cartilage, due to increased pressure on weight bearing joints. Furthermore, we present evidence to suggest a pro-tumorigenic effect of increased mechanical force on epithelial cells in contexts where PG-mediated, aligned collagen fibrous tissue abounds, with implications for breast cancer development attributable to high MD. Finally, we summarise means through which this positive feedback mechanism of PG synthesis may be intercepted to reduce mechanical force within tissues and thus reduce disease burden.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherSpringeren_US
dc.relation.ispartofjournalJournal of Mammary Gland Biology and Neoplasiaen_US
dc.subject.fieldofresearchClinical sciencesen_US
dc.subject.fieldofresearchOncology and carcinogenesisen_US
dc.subject.fieldofresearchcode3202en_US
dc.subject.fieldofresearchcode3211en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsEndocrinology & Metabolismen_US
dc.subject.keywordsPhysiologyen_US
dc.titleMechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationReye, G; Huang, X; Haupt, LM; Murphy, RJ; Northey, JJ; Thompson, EW; Momot, KI; Hugo, HJ, Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?, Journal of Mammary Gland Biology and Neoplasia, 2021en_US
dcterms.dateAccepted2021-07-05
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-09-16T01:24:12Z
dc.description.versionVersion of Record (VoR)en_US
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.en_US
gro.rights.copyright© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.en_US
gro.hasfulltextFull Text
gro.griffith.authorHugo, Honor J.


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