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dc.contributor.authorMurphy, Ryan J
dc.contributor.authorBuenzli, Pascal R
dc.contributor.authorTambyah, Tamara A
dc.contributor.authorThompson, Erik W
dc.contributor.authorHugo, Honor J
dc.contributor.authorBaker, Ruth E
dc.contributor.authorSimpson, Matthew J
dc.date.accessioned2021-09-16T04:12:43Z
dc.date.available2021-09-16T04:12:43Z
dc.date.issued2021
dc.identifier.issn1478-3967
dc.identifier.doi10.1088/1478-3975/abf425
dc.identifier.urihttp://hdl.handle.net/10072/408064
dc.description.abstractThe detachment of cells from the boundary of an epithelial tissue and the subsequent invasion of these cells into surrounding tissues is important for cancer development and wound healing, and is strongly associated with the epithelial-mesenchymal transition (EMT). Chemical signals, such as TGF-β, produced by surrounding tissue can be uptaken by cells and induce EMT. In this work, we present a novel cell-based discrete mathematical model of mechanical cellular relaxation, cell proliferation, and cell detachment driven by chemically-dependent EMT in an epithelial tissue. A continuum description of the model is then derived in the form of a novel nonlinear free boundary problem. Using the discrete and continuum models we explore how the coupling of chemical transport and mechanical interactions influences EMT, and postulate how this could be used to help control EMT in pathological situations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherIOP Publishing
dc.relation.ispartofpagefrom046001
dc.relation.ispartofissue4
dc.relation.ispartofjournalPhysical Biology
dc.relation.ispartofvolume18
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode51
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode40
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsBiophysics
dc.subject.keywordsepithelial-mesenchymal transition
dc.titleThe role of mechanical interactions in EMT
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMurphy, RJ; Buenzli, PR; Tambyah, TA; Thompson, EW; Hugo, HJ; Baker, RE; Simpson, MJ, The role of mechanical interactions in EMT, Physical Biology, 2021, 18 (4), pp. 046001
dcterms.dateAccepted2021-03-31
dc.date.updated2021-09-16T04:02:44Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 Institute of Physics Publishing. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher.Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorHugo, Honor J.


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