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  • Size-tuneable isolation of cancer cells using stretchable inertial microfluidics

    Author(s)
    Fallahi, Hedieh
    Yadav, Sharda
    Phan, Hoang-Phuong
    Ta, Hang
    Zhang, Jun
    Nguyen, Nam-Trung
    Griffith University Author(s)
    Zhang, Jun
    Ta, Hang
    Yadav, Sharda
    Fallahi, Hedieh
    Nguyen, Nam-Trung
    Phan, Hoang Phuong
    Year published
    2021
    Metadata
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    Abstract
    Inertial microfluidics is a simple, low cost, efficient size-based separation technique which is being widely investigated for rare-cell isolation and detection. Due to the fixed geometrical dimensions of the current rigid inertial microfluidic systems, most of them are only capable of isolating and separating cells with certain types and sizes. Herein, we report the design, fabrication, and validation of a stretchable inertial microfluidic device with a tuneable separation threshold that can be used for heterogenous mixtures of particles and cells. Stretchability allows for the fine-tuning of the critical sorting size, ...
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    Inertial microfluidics is a simple, low cost, efficient size-based separation technique which is being widely investigated for rare-cell isolation and detection. Due to the fixed geometrical dimensions of the current rigid inertial microfluidic systems, most of them are only capable of isolating and separating cells with certain types and sizes. Herein, we report the design, fabrication, and validation of a stretchable inertial microfluidic device with a tuneable separation threshold that can be used for heterogenous mixtures of particles and cells. Stretchability allows for the fine-tuning of the critical sorting size, resulting in a high separation resolution that makes the separation of cells with small size differences possible. We validated the tunability of the separation threshold by stretching the length of a microchannel to separate the particle sizes of interest. We also evaluated the focusing efficiency, flow behaviour, and the positions of cancer cells and white blood cells (WBCs) in an elongated channel, separately. In addition, the performance of the device was verified by isolating cancer cells from WBCs which revealed a high recovery rate and purity. The stretchable chip showed promising results in the separation of cells with comparable sizes. Further validation of the chip using whole blood spiked with cancer cells delivered a 98.6% recovery rate with 90% purity. Elongating a stretchable microfluidic chip enables onsite modification of the dimensions of a microchannel leading to a precise tunability of the separation threshold as well as a high separation resolution.
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    Journal Title
    Lab on a Chip
    Volume
    21
    Issue
    10
    DOI
    https://doi.org/10.1039/d1lc00082a
    Funder(s)
    ARC
    Grant identifier(s)
    DP180100055
    Subject
    Chemical sciences
    Engineering
    Science & Technology
    Life Sciences & Biomedicine
    Physical Sciences
    Biochemical Research Methods
    Publication URI
    http://hdl.handle.net/10072/408071
    Collection
    • Journal articles

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