dc.contributor.author | Dhanani, Jayesh | |
dc.contributor.author | Fraser, John F | |
dc.contributor.author | Chan, Hak-Kim | |
dc.contributor.author | Rello, Jordi | |
dc.contributor.author | Cohen, Jeremy | |
dc.contributor.author | Roberts, Jason A | |
dc.date.accessioned | 2023-06-11T23:14:39Z | |
dc.date.available | 2023-06-11T23:14:39Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1466-609X | en_US |
dc.identifier.doi | 10.1186/s13054-016-1448-5 | en_US |
dc.identifier.uri | http://hdl.handle.net/10072/408092 | |
dc.description.abstract | Drug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics-pharmacodynamics associated with systemic therapies. For many drug therapies, there is potential to use the respiratory system as an alternative route for drug delivery. Aerosol drug delivery can provide many advantages over conventional therapy. Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. To date, limited evidence has restricted its wider application. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). This review identifies the relevant factors which require attention for optimization of aerosol drug delivery that can achieve better drug concentrations at the target sites and potentially improve clinical outcomes. | en_US |
dc.description.peerreviewed | Yes | en_US |
dc.language | English | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartofissue | 1 | en_US |
dc.relation.ispartofjournal | Critical Care | en_US |
dc.relation.ispartofvolume | 20 | en_US |
dc.subject.fieldofresearch | Biomedical and clinical sciences | en_US |
dc.subject.fieldofresearchcode | 32 | en_US |
dc.subject.keywords | Science & Technology | en_US |
dc.subject.keywords | Life Sciences & Biomedicine | en_US |
dc.subject.keywords | Critical Care Medicine | en_US |
dc.subject.keywords | General & Internal Medicine | en_US |
dc.subject.keywords | MECHANICALLY VENTILATED PATIENTS | en_US |
dc.title | Fundamentals of aerosol therapy in critical care | en_US |
dc.type | Journal article | en_US |
dc.type.description | C1 - Articles | en_US |
dcterms.bibliographicCitation | Dhanani, J; Fraser, JF; Chan, H-K; Rello, J; Cohen, J; Roberts, JA, Fundamentals of aerosol therapy in critical care, Critical Care, 2016, 20 (1) | en_US |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.date.updated | 2021-09-20T04:19:18Z | |
dc.description.version | Version of Record (VoR) | en_US |
gro.rights.copyright | © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_US |
gro.hasfulltext | Full Text | |
gro.griffith.author | Fraser, John F. | |