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dc.contributor.authorDhanani, Jayesh
dc.contributor.authorFraser, John F
dc.contributor.authorChan, Hak-Kim
dc.contributor.authorRello, Jordi
dc.contributor.authorCohen, Jeremy
dc.contributor.authorRoberts, Jason A
dc.date.accessioned2023-06-11T23:14:39Z
dc.date.available2023-06-11T23:14:39Z
dc.date.issued2016
dc.identifier.issn1466-609Xen_US
dc.identifier.doi10.1186/s13054-016-1448-5en_US
dc.identifier.urihttp://hdl.handle.net/10072/408092
dc.description.abstractDrug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics-pharmacodynamics associated with systemic therapies. For many drug therapies, there is potential to use the respiratory system as an alternative route for drug delivery. Aerosol drug delivery can provide many advantages over conventional therapy. Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. To date, limited evidence has restricted its wider application. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). This review identifies the relevant factors which require attention for optimization of aerosol drug delivery that can achieve better drug concentrations at the target sites and potentially improve clinical outcomes.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherSpringeren_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalCritical Careen_US
dc.relation.ispartofvolume20en_US
dc.subject.fieldofresearchBiomedical and clinical sciencesen_US
dc.subject.fieldofresearchcode32en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsCritical Care Medicineen_US
dc.subject.keywordsGeneral & Internal Medicineen_US
dc.subject.keywordsMECHANICALLY VENTILATED PATIENTSen_US
dc.titleFundamentals of aerosol therapy in critical careen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationDhanani, J; Fraser, JF; Chan, H-K; Rello, J; Cohen, J; Roberts, JA, Fundamentals of aerosol therapy in critical care, Critical Care, 2016, 20 (1)en_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-09-20T04:19:18Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
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gro.griffith.authorFraser, John F.


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