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dc.contributor.authorMillar, Jonathan E
dc.contributor.authorFanning, Jonathon P
dc.contributor.authorMcDonald, Charles I
dc.contributor.authorMcAuley, Daniel F
dc.contributor.authorFraser, John F
dc.date.accessioned2021-09-20T04:28:07Z
dc.date.available2021-09-20T04:28:07Z
dc.date.issued2016
dc.identifier.issn1466-609X
dc.identifier.doi10.1186/s13054-016-1570-4
dc.identifier.urihttp://hdl.handle.net/10072/408094
dc.description.abstractExtracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-term mechanical support to the heart, lungs or both. Over the last decade, the number of centres offering ECMO has grown rapidly. At the same time, the indications for its use have also been broadened. In part, this trend has been supported by advances in circuit design and in cannulation techniques. Despite the widespread adoption of extracorporeal life support techniques, the use of ECMO remains associated with significant morbidity and mortality. A complication witnessed during ECMO is the inflammatory response to extracorporeal circulation. This reaction shares similarities with the systemic inflammatory response syndrome (SIRS) and has been well-documented in relation to cardiopulmonary bypass. The exposure of a patient's blood to the non-endothelialised surface of the ECMO circuit results in the widespread activation of the innate immune system; if unchecked this may result in inflammation and organ injury. Here, we review the pathophysiology of the inflammatory response to ECMO, highlighting the complex interactions between arms of the innate immune response, the endothelium and coagulation. An understanding of the processes involved may guide the design of therapies and strategies aimed at ameliorating inflammation during ECMO. Likewise, an appreciation of the potentially deleterious inflammatory effects of ECMO may assist those weighing the risks and benefits of therapy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSpringer
dc.relation.ispartofissue1
dc.relation.ispartofjournalCritical Care
dc.relation.ispartofvolume20
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCritical Care Medicine
dc.subject.keywordsGeneral & Internal Medicine
dc.subject.keywordsExtracorporeal membrane oxygenation
dc.titleThe inflammatory response to extracorporeal membrane oxygenation (ECMO): A review of the pathophysiology
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMillar, JE; Fanning, JP; McDonald, CI; McAuley, DF; Fraser, JF, The inflammatory response to extracorporeal membrane oxygenation (ECMO): A review of the pathophysiology, Critical Care, 2016, 20 (1)
dc.date.updated2021-09-20T04:25:11Z
gro.hasfulltextNo Full Text
gro.griffith.authorFraser, John F.


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