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dc.contributor.authorMahmud, M
dc.contributor.authorJing, MK
dc.contributor.authorIdris, A
dc.date.accessioned2021-09-21T04:34:48Z
dc.date.available2021-09-21T04:34:48Z
dc.date.issued2016
dc.identifier.issn1573-3955
dc.identifier.doi10.2174/1573395511666150706181159
dc.identifier.urihttp://hdl.handle.net/10072/408166
dc.description.abstractThe cells of the innate immune system continually undergo surveillance of the extracellular milieu to serve as the first line of defense against invading microbial pathogens. As a result, these innate immune cells have evolved receptors to sense microbial motifs and danger signals. The inflammasome is an important component of the innate immune system’s “arsenal” against invading microbes such as viruses and bacteria and acts as a homeostatic checkpoint to regulate inflammation. Inflammasomes are cytosolic multi-protein complexes that activate caspase 1 and 11, which result in the production of pro-inflammatory interleukin (IL)-1β and IL-18, and cell death. Several studies have uncovered the mechanisms of inflammasome activation in response to various stimuli ranging from environmental stimulants to microbial components. This mini-review summarizes the current developments and updates in the mechanism of action of inflammasomes.
dc.description.peerreviewedYes
dc.languageen
dc.publisherBentham Science Publishers
dc.relation.ispartofpagefrom27
dc.relation.ispartofpageto34
dc.relation.ispartofissue1
dc.relation.ispartofjournalCurrent Immunology Reviews
dc.relation.ispartofvolume12
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode3204
dc.titleInflammasomes – A mini-review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMahmud, M; Jing, MK; Idris, A, Inflammasomes – A mini-review, Current Immunology Reviews, 2016, 12 (1), pp. 27-34
dc.date.updated2021-09-21T04:33:14Z
gro.hasfulltextNo Full Text
gro.griffith.authorIdris, Adi


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