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dc.contributor.authorAhmed, Ishtiaq
dc.contributor.authorRehman, Saif Ur
dc.contributor.authorShahmohamadnejad, Shiva
dc.contributor.authorZia, Muhammad Anjum
dc.contributor.authorAhmad, Muhammad
dc.contributor.authorSaeed, Muhammad Muzammal
dc.contributor.authorAkram, Zain
dc.contributor.authorIqbal, Hafiz MN
dc.contributor.authorLiu, Qingyou
dc.date.accessioned2021-09-23T01:11:46Z
dc.date.available2021-09-23T01:11:46Z
dc.date.issued2021
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules26113389
dc.identifier.urihttp://hdl.handle.net/10072/408244
dc.description.abstractIn humans, various sites like cannabinoid receptors (CBR) having a binding affinity with cannabinoids are distributed on the surface of different cell types, where endocannabinoids (ECs) and derivatives of fatty acid can bind. The binding of these substance(s) triggers the activation of specific receptors required for various physiological functions, including pain sensation, memory, and appetite. The ECs and CBR perform multiple functions via the cannabinoid receptor 1 (CB1); cannabinoid receptor 2 (CB2), having a key effect in restraining neurotransmitters and the arrangement of cytokines. The role of cannabinoids in the immune system is illustrated because of their immunosuppressive characteristics. These characteristics include inhibition of leucocyte proliferation, T cells apoptosis, and induction of macrophages along with reduced pro-inflammatory cytokines secretion. The review seeks to discuss the functional relationship between the endocannabinoid system (ECS) and anti-tumor characteristics of cannabinoids in various cancers. The therapeutic potential of cannabinoids for cancer-both in vivo and in vitro clinical trials-has also been highlighted and reported to be effective in mice models in arthritis for the inflammation reduction, neuropathic pain, positive effect in multiple sclerosis and type-1 diabetes mellitus, and found beneficial for treating in various cancers. In human models, such studies are limited; thereby, further research is indispensable in this field to get a conclusive outcome. Therefore, in autoimmune disorders, therapeutic cannabinoids can serve as promising immunosuppressive and anti-fibrotic agents.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofpagefrom3389
dc.relation.ispartofissue11
dc.relation.ispartofjournalMolecules
dc.relation.ispartofvolume26
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchTheoretical and computational chemistry
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3407
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsChemistry, Multidisciplinary
dc.titleTherapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAhmed, I; Rehman, SU; Shahmohamadnejad, S; Zia, MA; Ahmad, M; Saeed, MM; Akram, Z; Iqbal, HMN; Liu, Q, Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders, Molecules, 2021, 26 (11), pp. 3389
dcterms.dateAccepted2021-05-29
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-09-22T03:15:22Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorAkram, Zain
gro.griffith.authorAhmed, Ishtiaq


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