dc.contributor.author | Yap, Lim Wei | |
dc.contributor.author | Chen, Huaying | |
dc.contributor.author | Gao, Yuan | |
dc.contributor.author | Petkovic, Karolina | |
dc.contributor.author | Liang, Yan | |
dc.contributor.author | Si, Kae Jye | |
dc.contributor.author | Wang, Huanting | |
dc.contributor.author | Tang, Zhiyong | |
dc.contributor.author | Zhu, Yonggang | |
dc.contributor.author | Cheng, Wenlong | |
dc.date.accessioned | 2021-09-23T23:53:22Z | |
dc.date.available | 2021-09-23T23:53:22Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2040-3364 | |
dc.identifier.doi | 10.1039/c7nr01511a | |
dc.identifier.uri | http://hdl.handle.net/10072/408315 | |
dc.description.abstract | Surface-Enhanced Raman Scattering (SERS) is emerging as a promising strategy for the quantification of immunoglobulin G (IgG) due to its inherent high sensitivity and specificity; however, it remains challenging to integrate SERS detection with a microfluidic system in a simple, efficient and low-cost manner. Here, we report on a novel bifunctional plasmonic-magnetic particle-based immunoassay, in which plasmonic nanoparticles act as soluble SERS immunosubstrates, whereas magnetic particles are for promoting micromixing in a microfluidic chip. With this novel SERS immunosubstrate in conjunction with the unique microfluidic system, we could substantially reduce the assay time from 4 hours to 80 minutes as well as enhance the detection specificity by about 70% in comparison to a non-microfluidic immunoassay. Compared to previous microfluidic SERS systems, our strategy offers a simple microfluidic chip design with only one well for mixing, washing and detection. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | ROYAL SOC CHEMISTRY | |
dc.relation.ispartofpagefrom | 7822 | |
dc.relation.ispartofpageto | 7829 | |
dc.relation.ispartofissue | 23 | |
dc.relation.ispartofjournal | Nanoscale | |
dc.relation.ispartofvolume | 9 | |
dc.subject.fieldofresearch | Physical sciences | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearchcode | 51 | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Physical Sciences | |
dc.subject.keywords | Technology | |
dc.subject.keywords | Chemistry, Multidisciplinary | |
dc.subject.keywords | Nanoscience & Nanotechnology | |
dc.title | Bifunctional plasmonic-magnetic particles for an enhanced microfluidic SERS immunoassay | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Yap, LW; Chen, H; Gao, Y; Petkovic, K; Liang, Y; Si, KJ; Wang, H; Tang, Z; Zhu, Y; Cheng, W, Bifunctional plasmonic-magnetic particles for an enhanced microfluidic SERS immunoassay, Nanoscale, 2017, 9 (23), pp. 7822-7829 | |
dc.date.updated | 2021-09-23T23:52:13Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Tang, Zhiyong | |