Molecular characterization of fosfomycin-resistant Escherichia coli urinary tract infection isolates from Australia (Letter)
Author(s)
Mowlaboccus, S
Daley, DA
Birdsall, J
Gottlieb, T
Merlino, J
Nimmo, GR
George, N
Korman, T
Streitberg, R
Robson, J
Peachey, G
Collignon, P
Bradbury, S
Rogers, BA
Coombs, GW
Griffith University Author(s)
Year published
2021
Metadata
Show full item recordAbstract
Fosfomycin is a broad-spectrum antibiotic that targets UDP-Nacetylglucosamine enolpyruvyl transferase (MurA), an important enzyme in the early stages of peptidoglycan biosynthesis. In Escherichia coli, fosfomycin resistance can occur through the presence of fos genes (typically fosA3) which encode fosfomycininactivating enzymes (FosA, FosC2), or by mutations in proteins important for the uptake of fosfomycin (CyaA, GlpT, PtsI, UhpA, UhpT) or for its action (MurA)Fosfomycin is a broad-spectrum antibiotic that targets UDP-Nacetylglucosamine enolpyruvyl transferase (MurA), an important enzyme in the early stages of peptidoglycan biosynthesis. In Escherichia coli, fosfomycin resistance can occur through the presence of fos genes (typically fosA3) which encode fosfomycininactivating enzymes (FosA, FosC2), or by mutations in proteins important for the uptake of fosfomycin (CyaA, GlpT, PtsI, UhpA, UhpT) or for its action (MurA)
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Journal Title
Clinical Microbiology and Infection
Volume
27
Issue
9
Subject
Clinical sciences
Medical bacteriology