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dc.contributor.authorde Azevedo Queiroz, Índia Olinta
dc.contributor.authorMachado, Thiago
dc.contributor.authorAlves, Camila Carneiro
dc.contributor.authorVasques, Ana Maria Veiga
dc.contributor.authorCury, Marina Tolomei Sandoval
dc.contributor.authorVasconcelos, Bruno Carvalho
dc.contributor.authorGomes-Filho, João Eduardo
dc.contributor.authorVivan, Rodrigo Ricci
dc.contributor.authorBraga, Tiago
dc.contributor.authorLove, Robert Matthew
dc.contributor.authorDuarte, Marco Antonio Hungaro
dc.description.abstractBACKGROUND: This study aimed to track the toxic ions released by MTA Fillapex, BioRoot RCS, and an experimental tricalcium silicate-based sealer (CEO) into local and distant tissues as well as to investigate their potential adverse effects. In addition, the chemical constituents of the sealers were also evaluated. The main components of the dry powders, pastes, and mixed sealers were characterized. MATERIAL AND METHODS: Dry powder and sealer discs were each set for 72 h and their main components were characterized by energy dispersive X-ray spectroscopy. Polyethylene tubes filled with sealers were used to measure silicon and calcium ions. Polyethylene tubes filled with sealers or empty tubes were implanted into the dorsal connective tissue of Wistar rats. On days 7, 15, 30, and 45, the animals were euthanized and their brains, livers, kidneys, and subcutaneous tissues were removed and processed to determine the concentrations of chromium, cobalt, copper, lead, iron, magnesium and nickel using an inductively coupled plasma optical emission spectrometer. RESULTS: The main compounds in all sealers were carbon, oxygen, silicon, and calcium. MTA Fillapex release more Si while highest levels of Si were found in presence of BioRoot. The release of Si and Ca ions promoted by MTA Fillapex raise by time. No traces of cobalt, chromium, or magnesium were detected in any tissue. Irrespective of the sealer, no traces of copper and lead were found in the subcutaneous tissue; however, they were observed in the organs. The highest concentration of iron was identified in the liver. All sealers exhibited similar nickel traces in the brain, kidney, and liver except for MTA Fillapex, which demonstrated levels higher than CEO in the subcutaneous tissue on day 7. Tracing nickel ions over time revealed that lowest concentrations were found in subcutaneous tissue. CONCLUSION: Taken together, our data demonstrate that CEOs have chemical compositions similar to those of other commercial sealers. Furthermore, none of them exhibited a threat to systemic health. Moreover, the minimal amounts of iron and nickel detected were not related to the sealers.
dc.publisherElsevier BV
dc.relation.ispartofjournalJournal of Trace Elements in Medicine and Biology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.keywordsBody organs
dc.subject.keywordsHeavy metal
dc.subject.keywordsRoot canal filling
dc.subject.keywordsSystemic effect
dc.subject.keywordsTricalcium silicate
dc.titleTracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationde Azevedo Queiroz, ÍO; Machado, T; Alves, CC; Vasques, AMV; Cury, MTS; Vasconcelos, BC; Gomes-Filho, JE; Vivan, RR; Braga, T; Love, RM; Duarte, MAH, Tracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs., Journal of Trace Elements in Medicine and Biology, 2021, 68, pp. 126856
gro.hasfulltextNo Full Text
gro.griffith.authorBraga, Tiago
gro.griffith.authorLove, Robert M.

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