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dc.contributor.authorLivingstone, SA
dc.contributor.authorWildi, KS
dc.contributor.authorDalton, HJ
dc.contributor.authorUsman, A
dc.contributor.authorKi, KK
dc.contributor.authorPassmore, MR
dc.contributor.authorLi Bassi, G
dc.contributor.authorSuen, JY
dc.contributor.authorFraser, JF
dc.date.accessioned2021-09-27T03:12:36Z
dc.date.available2021-09-27T03:12:36Z
dc.date.issued2021
dc.identifier.issn2296-858Xen_US
dc.identifier.doi10.3389/fmed.2021.723217en_US
dc.identifier.urihttp://hdl.handle.net/10072/408394
dc.description.abstractThe Acute Respiratory Distress Syndrome (ARDS) has caused innumerable deaths worldwide since its initial description over five decades ago. Population-based estimates of ARDS vary from 1 to 86 cases per 100,000, with the highest rates reported in Australia and the United States. This syndrome is characterised by a breakdown of the pulmonary alveolo-epithelial barrier with subsequent severe hypoxaemia and disturbances in pulmonary mechanics. The underlying pathophysiology of this syndrome is a severe inflammatory reaction and associated local and systemic coagulation dysfunction that leads to pulmonary and systemic damage, ultimately causing death in up to 40% of patients. Since inflammation and coagulation are inextricably linked throughout evolution, it is biological folly to assess the two systems in isolation when investigating the underlying molecular mechanisms of coagulation dysfunction in ARDS. Although the body possesses potent endogenous systems to regulate coagulation, these become dysregulated and no longer optimally functional during the acute phase of ARDS, further perpetuating coagulation, inflammation and cell damage. The inflammatory ARDS subphenotypes address inflammatory differences but neglect the equally important coagulation pathway. A holistic understanding of this syndrome and its subphenotypes will improve our understanding of underlying mechanisms that then drive translation into diagnostic testing, treatments, and improve patient outcomes.en_US
dc.description.peerreviewedYesen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofpagefrom723217en_US
dc.relation.ispartofjournalFrontiers in Medicineen_US
dc.relation.ispartofvolume8en_US
dc.subject.fieldofresearchClinical sciencesen_US
dc.subject.fieldofresearchRespiratory diseasesen_US
dc.subject.fieldofresearchHaematologyen_US
dc.subject.fieldofresearchcode3202en_US
dc.subject.fieldofresearchcode320103en_US
dc.subject.fieldofresearchcode320102en_US
dc.titleCoagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationLivingstone, SA; Wildi, KS; Dalton, HJ; Usman, A; Ki, KK; Passmore, MR; Li Bassi, G; Suen, JY; Fraser, JF, Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes, Frontiers in Medicine, 2021, 8, pp. 723217en_US
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-09-24T02:49:53Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2021 Livingstone, Wildi, Dalton, Usman, Ki, Passmore, Li Bassi, Suen and Fraser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.


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