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  • Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

    Author(s)
    Cully, Tanya R
    Murphy, Robyn M
    Roberts, Llion
    Raastad, Truls
    Fassett, Robert G
    Coombes, Jeff S
    Jayasinghe, Isuru D
    Launikonis, Bradley S
    Griffith University Author(s)
    Roberts, Llion A.
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    High-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane network inside the fibres, the tubular (t-) system, causing the loss of its predominantly transverse organization and an increase in vacuolation of its longitudinal tubules across adjacent sarcomeres. The transverse tubules and vacuoles displayed distinct Ca2+-handling properties. Both t-system components could take up Ca2+ from the cytoplasm but only transverse tubules supported ...
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    High-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane network inside the fibres, the tubular (t-) system, causing the loss of its predominantly transverse organization and an increase in vacuolation of its longitudinal tubules across adjacent sarcomeres. The transverse tubules and vacuoles displayed distinct Ca2+-handling properties. Both t-system components could take up Ca2+ from the cytoplasm but only transverse tubules supported store-operated Ca2+ entry. The retention of significant amounts of Ca2+ within vacuoles provides an effective mechanism to reduce the total content of Ca2+ within the fibre cytoplasm. We propose this ability can reduce or limit resistance exercise-induced, Ca2+-dependent damage to the fibre by the reduction of [Ca2+]cyto to help maintain fibre viability during the period associated with delayed onset muscle soreness.
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    Journal Title
    Nature Communications
    Volume
    8
    DOI
    https://doi.org/10.1038/ncomms14266
    Subject
    Sport and exercise psychology
    Sports science and exercise
    Science & Technology
    Multidisciplinary Sciences
    Science & Technology - Other Topics
    Operated CA2+ Entry
    Tubular System
    Publication URI
    http://hdl.handle.net/10072/408416
    Collection
    • Journal articles

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