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dc.contributor.authorCully, Tanya R
dc.contributor.authorMurphy, Robyn M
dc.contributor.authorRoberts, Llion
dc.contributor.authorRaastad, Truls
dc.contributor.authorFassett, Robert G
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorJayasinghe, Isuru D
dc.contributor.authorLaunikonis, Bradley S
dc.date.accessioned2021-09-27T04:37:27Z
dc.date.available2021-09-27T04:37:27Z
dc.date.issued2017
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/ncomms14266
dc.identifier.urihttp://hdl.handle.net/10072/408416
dc.description.abstractHigh-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane network inside the fibres, the tubular (t-) system, causing the loss of its predominantly transverse organization and an increase in vacuolation of its longitudinal tubules across adjacent sarcomeres. The transverse tubules and vacuoles displayed distinct Ca2+-handling properties. Both t-system components could take up Ca2+ from the cytoplasm but only transverse tubules supported store-operated Ca2+ entry. The retention of significant amounts of Ca2+ within vacuoles provides an effective mechanism to reduce the total content of Ca2+ within the fibre cytoplasm. We propose this ability can reduce or limit resistance exercise-induced, Ca2+-dependent damage to the fibre by the reduction of [Ca2+]cyto to help maintain fibre viability during the period associated with delayed onset muscle soreness.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofjournalNature Communications
dc.relation.ispartofvolume8
dc.subject.fieldofresearchSport and exercise psychology
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode520107
dc.subject.fieldofresearchcode4207
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsOperated CA2+ Entry
dc.subject.keywordsTubular System
dc.titleHuman skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCully, TR; Murphy, RM; Roberts, L; Raastad, T; Fassett, RG; Coombes, JS; Jayasinghe, ID; Launikonis, BS, Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise, Nature Communications, 2017, 8
dcterms.dateAccepted2016-12-08
dc.date.updated2021-09-27T04:35:26Z
gro.hasfulltextNo Full Text
gro.griffith.authorRoberts, Llion A.


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