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dc.contributor.authorCully, Tanya R
dc.contributor.authorMurphy, Robyn M
dc.contributor.authorRoberts, Llion
dc.contributor.authorRaastad, Truls
dc.contributor.authorFassett, Robert G
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorJayasinghe, Isuru D
dc.contributor.authorLaunikonis, Bradley S
dc.date.accessioned2023-06-09T03:38:53Z
dc.date.available2023-06-09T03:38:53Z
dc.date.issued2017
dc.identifier.issn2041-1723en_US
dc.identifier.doi10.1038/ncomms14266en_US
dc.identifier.urihttp://hdl.handle.net/10072/408416
dc.description.abstractHigh-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane network inside the fibres, the tubular (t-) system, causing the loss of its predominantly transverse organization and an increase in vacuolation of its longitudinal tubules across adjacent sarcomeres. The transverse tubules and vacuoles displayed distinct Ca2+-handling properties. Both t-system components could take up Ca2+ from the cytoplasm but only transverse tubules supported store-operated Ca2+ entry. The retention of significant amounts of Ca2+ within vacuoles provides an effective mechanism to reduce the total content of Ca2+ within the fibre cytoplasm. We propose this ability can reduce or limit resistance exercise-induced, Ca2+-dependent damage to the fibre by the reduction of [Ca2+]cyto to help maintain fibre viability during the period associated with delayed onset muscle soreness.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofjournalNature Communicationsen_US
dc.relation.ispartofvolume8en_US
dc.subject.fieldofresearchSport and exercise psychologyen_US
dc.subject.fieldofresearchSports science and exerciseen_US
dc.subject.fieldofresearchcode520107en_US
dc.subject.fieldofresearchcode4207en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsMultidisciplinary Sciencesen_US
dc.subject.keywordsScience & Technology - Other Topicsen_US
dc.subject.keywordsOperated CA2+ Entryen_US
dc.subject.keywordsTubular Systemen_US
dc.titleHuman skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exerciseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationCully, TR; Murphy, RM; Roberts, L; Raastad, T; Fassett, RG; Coombes, JS; Jayasinghe, ID; Launikonis, BS, Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise, Nature Communications, 2017, 8en_US
dcterms.dateAccepted2016-12-08
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-09-27T04:35:26Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
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gro.griffith.authorRoberts, Llion A.


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