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dc.contributor.authorCully, Tanya R
dc.contributor.authorMurphy, Robyn M
dc.contributor.authorRoberts, Llion
dc.contributor.authorRaastad, Truls
dc.contributor.authorFassett, Robert G
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorJayasinghe, Isuru D
dc.contributor.authorLaunikonis, Bradley S
dc.description.abstractHigh-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane network inside the fibres, the tubular (t-) system, causing the loss of its predominantly transverse organization and an increase in vacuolation of its longitudinal tubules across adjacent sarcomeres. The transverse tubules and vacuoles displayed distinct Ca2+-handling properties. Both t-system components could take up Ca2+ from the cytoplasm but only transverse tubules supported store-operated Ca2+ entry. The retention of significant amounts of Ca2+ within vacuoles provides an effective mechanism to reduce the total content of Ca2+ within the fibre cytoplasm. We propose this ability can reduce or limit resistance exercise-induced, Ca2+-dependent damage to the fibre by the reduction of [Ca2+]cyto to help maintain fibre viability during the period associated with delayed onset muscle soreness.
dc.relation.ispartofjournalNature Communications
dc.subject.fieldofresearchSport and exercise psychology
dc.subject.fieldofresearchSports science and exercise
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsOperated CA2+ Entry
dc.subject.keywordsTubular System
dc.titleHuman skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCully, TR; Murphy, RM; Roberts, L; Raastad, T; Fassett, RG; Coombes, JS; Jayasinghe, ID; Launikonis, BS, Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise, Nature Communications, 2017, 8
gro.hasfulltextNo Full Text
gro.griffith.authorRoberts, Llion A.

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