Show simple item record

dc.contributor.authorKrishnasamy, R
dc.contributor.authorHawley, CM
dc.contributor.authorStanton, T
dc.contributor.authorHowden, EJ
dc.contributor.authorBeetham, KS
dc.contributor.authorStrand, H
dc.contributor.authorLeano, R
dc.contributor.authorHaluska, BA
dc.contributor.authorCoombes, JS
dc.contributor.authorIsbel, NM
dc.date.accessioned2021-09-27T06:36:03Z
dc.date.available2021-09-27T06:36:03Z
dc.date.issued2016
dc.identifier.issn1320-5358
dc.identifier.doi10.1111/nep.12557
dc.identifier.urihttp://hdl.handle.net/10072/408423
dc.description.abstractAim Patients with chronic kidney disease (CKD) have a significant burden of dyspnoea and fatigue in spite having normal left ventricular (LV) ejection fraction (EF). Global longitudinal strain (GLS) can detect subtle changes in LV function. This study aimed to evaluate the relationship between LV function, functional capacity and quality of life (QOL) in CKD patients with preserved EF. Methods A cross-sectional study of patients with stage 3/4 CKD (n = 108). Clinical characteristics, biochemical data, functional capacity (6-min walk test (6MWT), timed up and go (TUG) test) and QOL (short form-12 (SF-12v2™)) were measured. Echocardiogram was used to assess GLS, EF and diastolic function (E/A, e' and E/e'). Results The mean age was 58.1 ± 9.9 years, 55.6% were men, estimated glomerular filtration rate was 44.8 ± 10.6 mL/min/1.73 m2, GLS was -18.5 ± 3.6% and 19.4% had impaired GLS (>-16%). Patients with impaired GLS had a significantly shorter 6MWT and slower TUG test compared with patients with preserved GLS. Bivariate analysis showed GLS and E/e' correlated with distance walked in 6MWT (GLS (r = -0.24, P = 0.02); E/e'(r = -0.38, P = 0.002)). Following adjustment for potential confounders, GLS remained independently associated with 6MWT (model R2 = 0.37, P < 0.001). Mean physical component.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofpagefrom108
dc.relation.ispartofpageto115
dc.relation.ispartofissue2
dc.relation.ispartofjournalNephrology
dc.relation.ispartofvolume21
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsejection fraction
dc.subject.keywordsfunctional capacity
dc.subject.keywordsglobal longitudinal strain
dc.subject.keywordsleft ventricular function
dc.subject.keywordsquality of life
dc.titleAssociation between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKrishnasamy, R; Hawley, CM; Stanton, T; Howden, EJ; Beetham, KS; Strand, H; Leano, R; Haluska, BA; Coombes, JS; Isbel, NM, Association between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction, Nephrology, 2016, 21 (2), pp. 108-115
dcterms.dateAccepted2015-07-02
dc.date.updated2021-09-27T06:35:08Z
gro.hasfulltextNo Full Text
gro.griffith.authorStanton, Tony


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record