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dc.contributor.authorDudok, Jacobus J
dc.contributor.authorMurtaza, Mariyam
dc.contributor.authorAlves, C Henrique
dc.contributor.authorRashbass, Pen
dc.contributor.authorWijnholds, Jan
dc.date.accessioned2021-09-27T23:35:09Z
dc.date.available2021-09-27T23:35:09Z
dc.date.issued2016
dc.identifier.issn0168-0102
dc.identifier.doi10.1016/j.neures.2016.01.001
dc.identifier.urihttp://hdl.handle.net/10072/408436
dc.description.abstractThe formation of a functionally integrated nervous system is dependent on a highly organized sequence of events that includes timely division and differentiation of progenitors. Several apical polarity proteins have been shown to play crucial roles during neurogenesis, however, the role of Crumbs 2 (CRB2) in cortical development has not previously been reported. Here, we show that conditional ablation of Crb2 in the murine dorsal telencephalon leads to defects in the maintenance of the apical complex. Furthermore, within the mutant dorsal telencephalon there is premature expression of differentiation proteins. We examined the physiological function of Crb2 on wild type genetic background as well as on background lacking Crb1. Telencephalon lacking CRB2 resulted in reduced levels of PALS1 and CRB3 from the apical complex, an increased number of mitotic cells and expanded neuronal domain. These defects are transient and therefore only result in rather mild cortical abnormalities. We show that CRB2 is required for maintenance of the apical polarity complex during development of the cortex and regulation of cell division, and that loss of CRB2 results in cortical abnormalities.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofpagefrom12
dc.relation.ispartofpageto23
dc.relation.ispartofjournalNeuroscience Research
dc.relation.ispartofvolume108
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsNeurosciences
dc.subject.keywordsNeurosciences & Neurology
dc.subject.keywordsCRB2
dc.titleCrumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDudok, JJ; Murtaza, M; Alves, CH; Rashbass, P; Wijnholds, J, Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon, Neuroscience Research, 2016, 108, pp. 12-23
dcterms.dateAccepted2016-01-12
dc.date.updated2021-09-27T23:33:59Z
gro.hasfulltextNo Full Text
gro.griffith.authorMurtaza, Mariyam


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