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dc.contributor.authorDavids, Charlie J
dc.contributor.authorNæss, Tore C
dc.contributor.authorMoen, Maria
dc.contributor.authorCumming, Kristoffer Toldnes
dc.contributor.authorHorwath, Oscar
dc.contributor.authorPsilander, Niklas
dc.contributor.authorEkblom, Björn
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorPeake, Jonathan M
dc.contributor.authorRaastad, Truls
dc.contributor.authorRoberts, Llion Arwyn
dc.date.accessioned2021-09-30T06:07:53Z
dc.date.available2021-09-30T06:07:53Z
dc.date.issued2021
dc.identifier.issn8750-7587
dc.identifier.doi10.1152/japplphysiol.00464.2021
dc.identifier.urihttp://hdl.handle.net/10072/408494
dc.description.abstractBlood flow restriction (BFR) with low-load resistance exercise (RE) is often used as a surrogate to traditional high-load RE to stimulate muscular adaptations, such as hypertrophy and strength. However, it is not clear whether such adaptations are achieved through similar cellular and molecular processes. We compared changes in muscle function, morphology and signaling pathways between these differing training protocols. Twenty-one males and females (mean ± SD: 24.3 ± 3.1 years) experienced with resistance training (4.9 ± 2.6 years) performed nine weeks of resistance training (three times per week) with either high-loads (75-80% 1RM; HL-RT), or low-loads with BFR (30-40% 1RM; LL-BFR). Before and after the training intervention, resting muscle biopsies were collected, and quadricep cross-sectional area (CSA), muscular strength and power were measured. Approximately 5 days following the intervention, the same individuals performed an additional 'acute' exercise session under the same conditions, and serial muscle biopsies were collected to assess hypertrophic- and ribosomal-based signaling stimuli. Quadricep CSA increased with both LL-BFR (7.4±4.3%) and HL-RT (4.6±2.9%), with no significant differences between training groups (p=0.37). Muscular strength also increased in both training groups, but with superior gains in squat 1RM occurring with HL-RT (p<0.01). Acute phosphorylation of several key proteins involved in hypertrophy signaling pathways, and expression of ribosomal RNA transcription factors occurred to a similar degree with LL-BFR and HL-RT (all p>0.05 for between-group comparisons). Together, these findings validate low-load resistance training with continuous BFR as an effective alternative to traditional high-load resistance training for increasing muscle hypertrophy in trained individuals.
dc.description.peerreviewedYes
dc.description.sponsorshipGriffith University
dc.languageeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofjournalJournal of Applied Physiology
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode42
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.keywordsHypertrophy
dc.subject.keywordsHypoxia
dc.subject.keywordsIschemia
dc.subject.keywordsKaatsu
dc.subject.keywordsOcclusion
dc.titleAcute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDavids, CJ; Næss, TC; Moen, M; Cumming, KT; Horwath, O; Psilander, N; Ekblom, B; Coombes, JS; Peake, JM; Raastad, T; Roberts, LA, Acute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals, Journal of Applied Physiology, 2021
dc.date.updated2021-09-30T05:36:34Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 American Physiological Society . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorRoberts, Llion A.


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