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dc.contributor.authorKoop, Meghan A
dc.contributor.authorLutke Schipholt, Ivo J
dc.contributor.authorScholten-Peeters, Gwendolyne GM
dc.contributor.authorCoppieters, Michel W
dc.date.accessioned2021-10-05T00:12:11Z
dc.date.available2021-10-05T00:12:11Z
dc.date.issued2021
dc.identifier.issn1526-2375
dc.identifier.doi10.1093/pm/pnab243
dc.identifier.urihttp://hdl.handle.net/10072/408516
dc.description.abstractOBJECTIVE: The association between low-grade systemic inflammation and musculoskeletal pain may be influenced by multiple factors. However, little is known about the relative importance of these factors, and few studies account for them. This Delphi study aimed to reach consensus on the most important confounders which influence the association between low-grade systemic inflammation and musculoskeletal pain. METHODS: The panel consisted of 48 experts. In Round 1, the experts proposed what they believed were important confounders. In Round 2, the experts indicated for each confounder whether they believed it was important (yes/no). At least 50% of experts had to indicate the confounder was important to be considered in the final round. In Round 3, the experts rated the importance of each confounder on a 7-point Likert scale. Consensus was reached if ≥ 75% of the experts considered the factor either extremely or moderately important. RESULTS: In Round 1, 120 confounders were proposed, which were synthesised into 38 distinct factors. In Round 2, 33 confounders met the criterion to be considered important. In Round 3, consensus was reached for 14 confounders: acute illness/trauma, immune disease, medication use, endocrine, nutritional, or metabolic disease, other musculoskeletal conditions, age, handling of blood samples, sex, cancer, body composition, pregnancy, cardiovascular disease, physical activity, and pain characteristics. CONCLUSIONS: These findings provide insight in the complexity of the association between low-grade systemic inflammation and musculoskeletal pain. Some factors currently listed as confounders may be re-classified as moderators or mediators as insights progress.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofjournalPain MedPain Medicine
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsChronic pain
dc.subject.keywordsCovariate
dc.subject.keywordsCytokines
dc.subject.keywordsImmune system
dc.subject.keywordsLow back pain
dc.titleIdentifying the most important confounders when assessing the association between low-grade systemic inflammation and musculoskeletal pain: A modified Delphi study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKoop, MA; Lutke Schipholt, IJ; Scholten-Peeters, GGM; Coppieters, MW, Identifying the most important confounders when assessing the association between low-grade systemic inflammation and musculoskeletal pain: A modified Delphi study, Pain Medicine, 2021
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2021-08-10T23:33:07Z
dc.description.versionVersion of Record (VoR)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCoppieters, Michel


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