Show simple item record

dc.contributor.authorHewson, C
dc.contributor.authorCapraro, D
dc.contributor.authorBurdach, J
dc.contributor.authorWhitaker, N
dc.contributor.authorMorris, KV
dc.date.accessioned2021-10-05T23:55:59Z
dc.date.available2021-10-05T23:55:59Z
dc.date.issued2016
dc.identifier.issn2468-0540en_US
dc.identifier.doi10.1016/j.ncrna.2016.06.001en_US
dc.identifier.urihttp://hdl.handle.net/10072/408589
dc.description.abstractCells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. We present evidence here that particular long non-coding RNA molecules are preferentially packaged into exosomes. We also find that a specific class of these exosome associated non-coding RNAs functionally modulate cell viability by direct interactions with L-lactate dehydrogenase B (LDHB), high-mobility group protein 17 (HMG-17), and CSF2RB, proteins involved in metabolism, nucleosomal architecture and cell signalling respectively. Knowledge of this endogenous cell to cell pathway, those proteins interacting with exosome associated non-coding transcripts and their interacting domains, could lead to a better understanding of not only cell to cell interactions but also the development of exosome targeted approaches in patient specific cell-based therapies.en_US
dc.description.peerreviewedYesen_US
dc.languageenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofpagefrom3en_US
dc.relation.ispartofpageto11en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalNon-coding RNA Researchen_US
dc.relation.ispartofvolume1en_US
dc.titleExtracellular vesicle associated long non-coding RNAs functionally enhance cell viabilityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationHewson, C; Capraro, D; Burdach, J; Whitaker, N; Morris, KV, Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability, Non-coding RNA Research, 2016, 1 (1), pp. 3-11en_US
dc.date.updated2021-10-05T23:54:50Z
gro.hasfulltextNo Full Text
gro.griffith.authorMorris, Kevin V.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record