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dc.contributor.authorHewson, C
dc.contributor.authorCapraro, D
dc.contributor.authorBurdach, J
dc.contributor.authorWhitaker, N
dc.contributor.authorMorris, KV
dc.description.abstractCells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. We present evidence here that particular long non-coding RNA molecules are preferentially packaged into exosomes. We also find that a specific class of these exosome associated non-coding RNAs functionally modulate cell viability by direct interactions with L-lactate dehydrogenase B (LDHB), high-mobility group protein 17 (HMG-17), and CSF2RB, proteins involved in metabolism, nucleosomal architecture and cell signalling respectively. Knowledge of this endogenous cell to cell pathway, those proteins interacting with exosome associated non-coding transcripts and their interacting domains, could lead to a better understanding of not only cell to cell interactions but also the development of exosome targeted approaches in patient specific cell-based therapies.en_US
dc.publisherElsevier BVen_US
dc.relation.ispartofjournalNon-coding RNA Researchen_US
dc.titleExtracellular vesicle associated long non-coding RNAs functionally enhance cell viabilityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationHewson, C; Capraro, D; Burdach, J; Whitaker, N; Morris, KV, Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability, Non-coding RNA Research, 2016, 1 (1), pp. 3-11en_US
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gro.griffith.authorMorris, Kevin V.

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    Contains articles published by Griffith authors in scholarly journals.

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