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dc.contributor.authorHewson, C
dc.contributor.authorCapraro, D
dc.contributor.authorBurdach, J
dc.contributor.authorWhitaker, N
dc.contributor.authorMorris, KV
dc.date.accessioned2021-10-05T23:55:59Z
dc.date.available2021-10-05T23:55:59Z
dc.date.issued2016
dc.identifier.issn2468-0540
dc.identifier.doi10.1016/j.ncrna.2016.06.001
dc.identifier.urihttp://hdl.handle.net/10072/408589
dc.description.abstractCells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. We present evidence here that particular long non-coding RNA molecules are preferentially packaged into exosomes. We also find that a specific class of these exosome associated non-coding RNAs functionally modulate cell viability by direct interactions with L-lactate dehydrogenase B (LDHB), high-mobility group protein 17 (HMG-17), and CSF2RB, proteins involved in metabolism, nucleosomal architecture and cell signalling respectively. Knowledge of this endogenous cell to cell pathway, those proteins interacting with exosome associated non-coding transcripts and their interacting domains, could lead to a better understanding of not only cell to cell interactions but also the development of exosome targeted approaches in patient specific cell-based therapies.
dc.description.peerreviewedYes
dc.languageen
dc.publisherElsevier BV
dc.relation.ispartofpagefrom3
dc.relation.ispartofpageto11
dc.relation.ispartofissue1
dc.relation.ispartofjournalNon-coding RNA Research
dc.relation.ispartofvolume1
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode3105
dc.titleExtracellular vesicle associated long non-coding RNAs functionally enhance cell viability
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHewson, C; Capraro, D; Burdach, J; Whitaker, N; Morris, KV, Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability, Non-coding RNA Research, 2016, 1 (1), pp. 3-11
dc.date.updated2021-10-05T23:54:50Z
gro.hasfulltextNo Full Text
gro.griffith.authorMorris, Kevin V.


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