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dc.contributor.authorLepletier, A
dc.contributor.authorAlsharif, A
dc.contributor.authorChidgey, Ann P
dc.contributor.editorSavino, W
dc.contributor.editorGuaraldi, F
dc.date.accessioned2021-10-07T03:38:20Z
dc.date.available2021-10-07T03:38:20Z
dc.date.issued2017
dc.identifier.issn0301-3073
dc.identifier.doi10.1159/000452903
dc.identifier.urihttp://hdl.handle.net/10072/408714
dc.description.abstractThe thymus is primarily responsible for T cell production. However, it begins to recede in size and function, from early in life. This decreased generation of naive T cells during normal thymus ageing, or linked with pathology (i.e. chronic inflammation), leads to reduced T cell specificities, peripheral T cell imbalances, and higher susceptibilities to infections. Various clinical strategies for thymus and T cell recovery have been investigated, although no effective clinical treatments for the reconstitution of peripheral T cell diversity in severe immune deficiencies are available. The recent identification of thymic epithelial progenitor cells (TEPC) in the adult thymus will enable investigations into a new generation of therapies focused on regenerating the thymic microenvironment for diverse specificity T cell reconstitution in the elderly. The specific mechanisms underlying TEPC activation are still being investigated. Recent data point to an important role of the intrathymic transforming growth factor-β (TGF-β) circuitry. Although dual actions of this cytokine have been reported in the immune system, TGF-β signaling is transiently activated in hematopoietic stem and progenitor cells during hematopoietic regeneration. This review investigates the current strategies for thymus reactivation to replenish the peripheral T cell repertoire and potentially reverse the age-related inflammatory milieu.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherKarger
dc.relation.ispartofpagefrom19
dc.relation.ispartofpageto36
dc.relation.ispartofjournalEndocrine Immunology
dc.relation.ispartofvolume48
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEndocrinology & Metabolism
dc.subject.keywordsBONE-MARROW-TRANSPLANTATION
dc.subject.keywordsEMBRYONIC STEM-CELLS
dc.titleInflammation and thymus ageing
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLepletier, A; Alsharif, A; Chidgey, AP, Inflammation and thymus ageing, Endocrine Immunology, 2017, 48, pp. 19-36
dc.date.updated2021-10-07T03:36:04Z
gro.hasfulltextNo Full Text
gro.griffith.authorLepletier De Oliveira, Ailin


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