dc.contributor.author | Lepletier, A | |
dc.contributor.author | Alsharif, A | |
dc.contributor.author | Chidgey, Ann P | |
dc.contributor.editor | Savino, W | |
dc.contributor.editor | Guaraldi, F | |
dc.date.accessioned | 2021-10-07T03:38:20Z | |
dc.date.available | 2021-10-07T03:38:20Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0301-3073 | |
dc.identifier.doi | 10.1159/000452903 | |
dc.identifier.uri | http://hdl.handle.net/10072/408714 | |
dc.description.abstract | The thymus is primarily responsible for T cell production. However, it begins to recede in size and function, from early in life. This decreased generation of naive T cells during normal thymus ageing, or linked with pathology (i.e. chronic inflammation), leads to reduced T cell specificities, peripheral T cell imbalances, and higher susceptibilities to infections. Various clinical strategies for thymus and T cell recovery have been investigated, although no effective clinical treatments for the reconstitution of peripheral T cell diversity in severe immune deficiencies are available. The recent identification of thymic epithelial progenitor cells (TEPC) in the adult thymus will enable investigations into a new generation of therapies focused on regenerating the thymic microenvironment for diverse specificity T cell reconstitution in the elderly. The specific mechanisms underlying TEPC activation are still being investigated. Recent data point to an important role of the intrathymic transforming growth factor-β (TGF-β) circuitry. Although dual actions of this cytokine have been reported in the immune system, TGF-β signaling is transiently activated in hematopoietic stem and progenitor cells during hematopoietic regeneration. This review investigates the current strategies for thymus reactivation to replenish the peripheral T cell repertoire and potentially reverse the age-related inflammatory milieu. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | Karger | |
dc.relation.ispartofpagefrom | 19 | |
dc.relation.ispartofpageto | 36 | |
dc.relation.ispartofjournal | Endocrine Immunology | |
dc.relation.ispartofvolume | 48 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Endocrinology & Metabolism | |
dc.subject.keywords | BONE-MARROW-TRANSPLANTATION | |
dc.subject.keywords | EMBRYONIC STEM-CELLS | |
dc.title | Inflammation and thymus ageing | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Lepletier, A; Alsharif, A; Chidgey, AP, Inflammation and thymus ageing, Endocrine Immunology, 2017, 48, pp. 19-36 | |
dc.date.updated | 2021-10-07T03:36:04Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Lepletier De Oliveira, Ailin | |