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  • Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review

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    Martins De Mello Neto511026-Published.pdf (1.000Mb)
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    Author(s)
    de Mello-Neto, Joao Martins
    Nunes, Jessica Gomes Rodrigues
    Tadakamadla, Santosh Kumar
    da Silva Figueredo, Carlos Marcelo
    Griffith University Author(s)
    da Silva Figueredo, Carlos Marcelo
    Year published
    2021
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    Abstract
    This systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. A total of 6 cross-sectional studies of 275 patients were included. Immunological analyses were performed in gingival crevicular fluid, saliva, serum, intestinal and gingival biopsies. Four studies identified that the presence of ...
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    This systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. A total of 6 cross-sectional studies of 275 patients were included. Immunological analyses were performed in gingival crevicular fluid, saliva, serum, intestinal and gingival biopsies. Four studies identified that the presence of IBD and periodontal disease was associated with higher levels of prostaglandin E2, aMMP8, IL-18 and S100A12, respectively, when compared to patients without the coexistence of both diseases. Furthermore, another study identified higher aMMP-8 levels with increasing severity of periodontitis in Crohn’s disease patients. The quality of overall evidence ranged from high to low due to the observational nature of contributing studies. The coexistence of IBD and periodontal disease seems to be associated with a more responsive inflammatory reaction compared with individuals having one or the other. More randomized controlled studies evaluating the coexistence of IBD and periodontitis are required to better explore the immunological interplay between them.
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    Journal Title
    International Journal of Environmental Research and Public Health
    Volume
    18
    Issue
    17
    DOI
    https://doi.org/10.3390/ijerph18178958
    Copyright Statement
    © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Immunology
    Dentistry
    Periodontics
    Science & Technology
    Life Sciences & Biomedicine
    Environmental Sciences
    Public, Environmental & Occupational Health
    Environmental Sciences & Ecology
    Publication URI
    http://hdl.handle.net/10072/408777
    Collection
    • Journal articles

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