dc.contributor.author | de Mello-Neto, Joao Martins | |
dc.contributor.author | Nunes, Jessica Gomes Rodrigues | |
dc.contributor.author | Tadakamadla, Santosh Kumar | |
dc.contributor.author | da Silva Figueredo, Carlos Marcelo | |
dc.date.accessioned | 2021-10-11T03:41:38Z | |
dc.date.available | 2021-10-11T03:41:38Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1661-7827 | |
dc.identifier.doi | 10.3390/ijerph18178958 | |
dc.identifier.uri | http://hdl.handle.net/10072/408777 | |
dc.description.abstract | This systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. A total of 6 cross-sectional studies of 275 patients were included. Immunological analyses were performed in gingival crevicular fluid, saliva, serum, intestinal and gingival biopsies. Four studies identified that the presence of IBD and periodontal disease was associated with higher levels of prostaglandin E2, aMMP8, IL-18 and S100A12, respectively, when compared to patients without the coexistence of both diseases. Furthermore, another study identified higher aMMP-8 levels with increasing severity of periodontitis in Crohn’s disease patients. The quality of overall evidence ranged from high to low due to the observational nature of contributing studies. The coexistence of IBD and periodontal disease seems to be associated with a more responsive inflammatory reaction compared with individuals having one or the other. More randomized controlled studies evaluating the coexistence of IBD and periodontitis are required to better explore the immunological interplay between them. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | MDPI | |
dc.relation.ispartofpagefrom | 8958 | |
dc.relation.ispartofissue | 17 | |
dc.relation.ispartofjournal | International Journal of Environmental Research and Public Health | |
dc.relation.ispartofvolume | 18 | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearch | Dentistry | |
dc.subject.fieldofresearch | Periodontics | |
dc.subject.fieldofresearchcode | 3204 | |
dc.subject.fieldofresearchcode | 3203 | |
dc.subject.fieldofresearchcode | 320310 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Environmental Sciences | |
dc.subject.keywords | Public, Environmental & Occupational Health | |
dc.subject.keywords | Environmental Sciences & Ecology | |
dc.title | Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | de Mello-Neto, JM; Nunes, JGR; Tadakamadla, SK; da Silva Figueredo, CM, Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review, International Journal of Environmental Research and Public Health, 2021, 18 (17), pp. 8958 | |
dcterms.dateAccepted | 2021-08-23 | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2021-10-06T04:17:52Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | da Silva Figueredo, Carlos Marcelo | |