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dc.contributor.authorde Mello-Neto, Joao Martins
dc.contributor.authorNunes, Jessica Gomes Rodrigues
dc.contributor.authorTadakamadla, Santosh Kumar
dc.contributor.authorda Silva Figueredo, Carlos Marcelo
dc.date.accessioned2021-10-11T03:41:38Z
dc.date.available2021-10-11T03:41:38Z
dc.date.issued2021
dc.identifier.issn1661-7827
dc.identifier.doi10.3390/ijerph18178958
dc.identifier.urihttp://hdl.handle.net/10072/408777
dc.description.abstractThis systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. A total of 6 cross-sectional studies of 275 patients were included. Immunological analyses were performed in gingival crevicular fluid, saliva, serum, intestinal and gingival biopsies. Four studies identified that the presence of IBD and periodontal disease was associated with higher levels of prostaglandin E2, aMMP8, IL-18 and S100A12, respectively, when compared to patients without the coexistence of both diseases. Furthermore, another study identified higher aMMP-8 levels with increasing severity of periodontitis in Crohn’s disease patients. The quality of overall evidence ranged from high to low due to the observational nature of contributing studies. The coexistence of IBD and periodontal disease seems to be associated with a more responsive inflammatory reaction compared with individuals having one or the other. More randomized controlled studies evaluating the coexistence of IBD and periodontitis are required to better explore the immunological interplay between them.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofpagefrom8958
dc.relation.ispartofissue17
dc.relation.ispartofjournalInternational Journal of Environmental Research and Public Health
dc.relation.ispartofvolume18
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchPeriodontics
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode320310
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEnvironmental Sciences
dc.subject.keywordsPublic, Environmental & Occupational Health
dc.subject.keywordsEnvironmental Sciences & Ecology
dc.titleImmunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationde Mello-Neto, JM; Nunes, JGR; Tadakamadla, SK; da Silva Figueredo, CM, Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review, International Journal of Environmental Research and Public Health, 2021, 18 (17), pp. 8958
dcterms.dateAccepted2021-08-23
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-10-06T04:17:52Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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gro.griffith.authorda Silva Figueredo, Carlos Marcelo


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