dc.contributor.author | Ramkrishna, J | |
dc.contributor.author | Menezes, M | |
dc.contributor.author | Humnabadkar, K | |
dc.contributor.author | Tse, C | |
dc.contributor.author | Maxfield, MJ | |
dc.contributor.author | da Silva Costa, F | |
dc.contributor.author | Rolnik, DL | |
dc.contributor.author | Meagher, S | |
dc.date.accessioned | 2021-10-11T06:46:11Z | |
dc.date.available | 2021-10-11T06:46:11Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0197-3851 | |
dc.identifier.doi | 10.1002/pd.5847 | |
dc.identifier.uri | http://hdl.handle.net/10072/408824 | |
dc.description.abstract | Objective: To investigate the incidence of structural and chromosomal abnormalities in cases of fetal edema on early ultrasound prior to non-invasive prenatal testing (NIPT). Methods: A retrospective study of women undergoing pre-NIPT ultrasound with fetal crown-rump length (CRL) of 28 to 44 mm was conducted at a tertiary obstetric ultrasound clinic in Melbourne, Australia. Cases of reported fetal edema were included, and subclassified as isolated nuchal edema (>2.2 mm) or generalized edema/hydrops by two operators blinded to outcomes. Results: We identified 104 cases of fetal edema. Nuchal edema and generalized edema were present in 40 (38.5%) and 64 (61.5%) cases, respectively. Relevant chromosomal anomalies were identified in 19.2% (20/104), occurring in 10.0% (4/40) of the nuchal edema and 25.0% (16/64) of the generalized edema/hydrops cases. Structural anomalies with normal karyotype occurred in four (3.8%) additional cases. Miscarriage occurred in four cases (3.8%) and termination of pregnancy in 18 cases (17.3%). Among cases that reached the 11 to 13+6 weeks ultrasound, the edema resolved in 81.9% and these cases had less adverse outcomes than those with NT≥3.5 mm (10.9% vs 76.5%, P <.001). Conclusions: Fetal edema in early pregnancy is associated with a high incidence of structural and/or chromosomal abnormalities; these rates increase with progressive severity. | |
dc.description.peerreviewed | Yes | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofpagefrom | 241 | |
dc.relation.ispartofpageto | 247 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Prenatal Diagnosis | |
dc.relation.ispartofvolume | 41 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Paediatrics | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3213 | |
dc.title | Outcomes following the detection of fetal edema in early pregnancy prior to non-invasive prenatal testing | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Ramkrishna, J; Menezes, M; Humnabadkar, K; Tse, C; Maxfield, MJ; da Silva Costa, F; Rolnik, DL; Meagher, S, Outcomes following the detection of fetal edema in early pregnancy prior to non-invasive prenatal testing, Prenatal Diagnosis, 2021, 41 (2), pp. 241-247 | |
dcterms.dateAccepted | 2020-09-29 | |
dc.date.updated | 2021-10-07T04:14:16Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Da Silva Costa, Fabricio | |