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  • Cholangiocarcinoma following external beam radiotherapy: A report of two cases

    Author(s)
    Kulkarni, Anisha
    Gundara, Justin S
    Gill, Anthony J
    Hugh, Thomas J
    Samra, Jaswinder S
    Griffith University Author(s)
    Gundara, Justin
    Year published
    2017
    Metadata
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    Abstract
    Cholangiocarcinoma (CCA) is a relatively rare primary malignancy, with established risk factors that include primary sclerosing cholangitis, choledochal cysts and hepatoli-thiasis. In the present study, two cases of CCA, which occurred following abdominal external beam radiotherapy (EBRT) for non-Hodgkin’s lymphoma, are reported. Case 1 and 2 were diagnosed with cholangiocarcinoma 30 and 4 years following treatment with combined chemotherapy and abdominal radiotherapy treatment, respectively. The patients received chemotherapy as treatment of cholangiocarcinoma; however, whilst their symptoms improved, they succumbed within ...
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    Cholangiocarcinoma (CCA) is a relatively rare primary malignancy, with established risk factors that include primary sclerosing cholangitis, choledochal cysts and hepatoli-thiasis. In the present study, two cases of CCA, which occurred following abdominal external beam radiotherapy (EBRT) for non-Hodgkin’s lymphoma, are reported. Case 1 and 2 were diagnosed with cholangiocarcinoma 30 and 4 years following treatment with combined chemotherapy and abdominal radiotherapy treatment, respectively. The patients received chemotherapy as treatment of cholangiocarcinoma; however, whilst their symptoms improved, they succumbed within 12 and 2 months respectively following the diagnosis with chol-angiocarcinoma. Currently, the association between radiation exposure and hepatobiliary malignancy remains unclear, however, we hypothesize that biliary epithelium sensitivity to ionizing radiation may have contributed to the etiology of the secondary malignancies observed in these two patients. This study indicates that patients treated with abdominal EBRT may benefit from a heightened index of suspicion and more intensive surveillance for secondary biliary malignancies.
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    Journal Title
    Oncology Letters
    Volume
    14
    DOI
    https://doi.org/10.3892/ol.2017.6113
    Subject
    Oncology and carcinogenesis
    Gastroenterology and hepatology
    Nephrology and urology
    Science & Technology
    Life Sciences & Biomedicine
    Oncology
    cholangiocarcinoma
    radiotherapy
    Publication URI
    http://hdl.handle.net/10072/408832
    Collection
    • Journal articles

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