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dc.contributor.authorAl-hebshi, Nezar N
dc.contributor.authorNasher, Akram T
dc.contributor.authorSpeicher, David J
dc.contributor.authorShaikh, Mushfiq H
dc.contributor.authorJohnson, Newell W
dc.date.accessioned2021-10-12T01:06:40Z
dc.date.available2021-10-12T01:06:40Z
dc.date.issued2016
dc.identifier.issn1368-8375
dc.identifier.doi10.1016/j.oraloncology.2016.06.005
dc.identifier.urihttp://hdl.handle.net/10072/408851
dc.description.abstractEpstein–Barr virus (EBV), a gamma-1 herpesvirus, has tropism for B lymphocytes and epithelial cells of the upper aerodigestive tract. Despite most adults being asymptomatic carriers of an EBV infection obtained during adolescence, in some individuals EBV is oncogenic: it drives several types of lymphoma and some epithelial malignancies, principally nasopharyngeal carcinoma (NPC). EBV latent membrane protein 1 (LMP1), an active transmembrane receptor, appears to mediate malignant transformation by activating the nuclear-factor-kappa B (NF-ᴋB), c-Jun N-terminal kinase (JNK) and phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofpagefromE4
dc.relation.ispartofpagetoE5
dc.relation.ispartofjournalOral Oncology
dc.relation.ispartofvolume59
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsDentistry, Oral Surgery & Medicine
dc.subject.keywordsEpstein-Barr-Virus
dc.titlePossible interaction between tobacco use and EBV in oral squamous cell carcinoma (Letter)
dc.typeJournal article
dc.type.descriptionC3 - Articles (Letter/ Note)
dcterms.bibliographicCitationAl-hebshi, NN; Nasher, AT; Speicher, DJ; Shaikh, MH; Johnson, NW, Possible interaction between tobacco use and EBV in oral squamous cell carcinoma (Letter), Oral Oncology, 2016, 59, pp. E4-E5
dcterms.dateAccepted2016-06-07
dc.date.updated2021-10-12T01:04:17Z
gro.hasfulltextNo Full Text
gro.griffith.authorSpeicher, David J.
gro.griffith.authorJohnson, Newell W.
gro.griffith.authorShaikh, Mushfiq


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