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  • Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation

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    Author(s)
    J. Umbers, Alexandra
    Boeuf, Philippe
    Clapham, Caroline
    I. Stanisic, Danielle
    Baiwog, Francesca
    Mueller, Ivo
    Siba, Peter
    L. King, Christopher
    G. Beeson, James
    Glazier, Jocelyn
    J. Rogerson, Stephen
    Griffith University Author(s)
    Stanisic, Danielle
    Year published
    2011
    Metadata
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    Abstract
    Background. The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth. Method. We measured IGF-1 and IGF-2 concentrations in plasma from 88 mother-neonate pairs at delivery and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3, respectively) in cord plasma from a cohort of Papua New Guinean women with and without placental malaria. Messenger RNA levels of IGF-1, IGF-2, and the IGF ...
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    Background. The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth. Method. We measured IGF-1 and IGF-2 concentrations in plasma from 88 mother-neonate pairs at delivery and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3, respectively) in cord plasma from a cohort of Papua New Guinean women with and without placental malaria. Messenger RNA levels of IGF-1, IGF-2, and the IGF receptors were measured in matched placental biopsy specimens. Results. Compared with those for uninfected pregnancies, IGF-1 levels were reduced by 28% in plasma samples from women with placental Plasmodium falciparum infection and associated inflammation (P = .007) and by 25% in their neonates (P = .002). Levels of fetal IGFBP-1 were elevated in placental malaria with and without inflammation (P = .08 and P = .006, respectively) compared with uninfected controls. IGF-2 and IGFBP-3 plasma concentrations and placental IGF ligand and receptor messenger RNA transcript levels were similar across groups. Conclusion. Placental malaria-associated inflammation disturbs maternal and fetal levels of IGFs, which regulate fetal growth. This may be one mechanism by which placental malaria leads to fetal growth restriction.
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    Journal Title
    Journal of Infectious Diseases
    Volume
    203
    Issue
    4
    DOI
    https://doi.org/10.1093/infdis/jiq080
    Copyright Statement
    © 2011 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in The Journal of Geology. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Immunology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/40889
    Collection
    • Journal articles

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