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dc.contributor.authorJ. Umbers, Alexandra
dc.contributor.authorBoeuf, Philippe
dc.contributor.authorClapham, Caroline
dc.contributor.authorI. Stanisic, Danielle
dc.contributor.authorBaiwog, Francesca
dc.contributor.authorMueller, Ivo
dc.contributor.authorSiba, Peter
dc.contributor.authorL. King, Christopher
dc.contributor.authorG. Beeson, James
dc.contributor.authorGlazier, Jocelyn
dc.contributor.authorJ. Rogerson, Stephen
dc.date.accessioned2017-05-03T16:01:43Z
dc.date.available2017-05-03T16:01:43Z
dc.date.issued2011
dc.date.modified2012-04-29T22:10:35Z
dc.identifier.issn00221899
dc.identifier.doi10.1093/infdis/jiq080
dc.identifier.urihttp://hdl.handle.net/10072/40889
dc.description.abstractBackground. The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth. Method. We measured IGF-1 and IGF-2 concentrations in plasma from 88 mother-neonate pairs at delivery and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3, respectively) in cord plasma from a cohort of Papua New Guinean women with and without placental malaria. Messenger RNA levels of IGF-1, IGF-2, and the IGF receptors were measured in matched placental biopsy specimens. Results. Compared with those for uninfected pregnancies, IGF-1 levels were reduced by 28% in plasma samples from women with placental Plasmodium falciparum infection and associated inflammation (P = .007) and by 25% in their neonates (P = .002). Levels of fetal IGFBP-1 were elevated in placental malaria with and without inflammation (P = .08 and P = .006, respectively) compared with uninfected controls. IGF-2 and IGFBP-3 plasma concentrations and placental IGF ligand and receptor messenger RNA transcript levels were similar across groups. Conclusion. Placental malaria-associated inflammation disturbs maternal and fetal levels of IGFs, which regulate fetal growth. This may be one mechanism by which placental malaria leads to fetal growth restriction.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent184005 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom561
dc.relation.ispartofpageto569
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume203
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320499
dc.titlePlacental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in The Journal of Geology. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorStanisic, Danielle


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