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dc.contributor.authorChen, Yiqin
dc.contributor.authorMcLachlan, Michael S
dc.contributor.authorKaserzon, Sarit
dc.contributor.authorWang, Xianyu
dc.contributor.authorWeijs, Liesbeth
dc.contributor.authorGallen, Michael
dc.contributor.authorToms, Leisa-Maree L
dc.contributor.authorLi, Yan
dc.contributor.authorAylward, Lesa L
dc.contributor.authorSly, Peter D
dc.contributor.authorMueller, Jochen F
dc.description.abstractPrevious studies have found that the concentrations of a range of persistent organic pollutants (POPs) in faeces is linearly proportional to the POP concentrations in blood of human adults irrespective of age and gender. In order to investigate the correlation between POP concentrations in faeces and blood in infants, the monthly variation of POP concentrations in faeces over the first year of life of one infant was investigated in this study and compared to modelled blood concentrations. Faecal samples were collected from one male infant daily. The samples were pooled by month and analysed for three selected POPs (2,2',4,4',5,5'-Hexachlorobiphenyl (PCB153), p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and 2,2',4,4'-tetrabromodiphenyl ether (BDE47)). The POP concentrations in faecal samples increased for the first four months by a factor of 2.9, 4.9 and 1.4 for PCB153, BDE47, and p,p'-DDE, respectively. The faecal concentrations of all POPs decreased rapidly following the introduction of formula and solid food to the diet and subsequent weaning of the infant. Further, a one-compartment model was developed to estimate the daily POP concentrations in the blood of the infant. The POP concentrations in blood were predicted to vary much less over the first year than those observed in faeces. The faeces:blood concentration ratio of selected POPs (Kfb) differed significantly (P<0.0001) between the period before and after weaning, and observed changes in Kfb are far greater than the uncertainty in the estimated Kfb. A more stable Kfb after weaning indicates the possibility of applying the stable Kfb values for non-invasive assessment of internal exposure in infants after weaning. The intra-individual variation in Kfb in infants is worthy of further investigation.
dc.relation.ispartofjournalEnvironmental Research
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEnvironmental Sciences
dc.subject.keywordsPublic, Environmental & Occupational Health
dc.subject.keywordsEnvironmental Sciences & Ecology
dc.titleMonthly variation in faeces: Blood concentration ratio of persistent organic pollutants over the first year of life: A case study of one infant
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChen, Y; McLachlan, MS; Kaserzon, S; Wang, X; Weijs, L; Gallen, M; Toms, L-ML; Li, Y; Aylward, LL; Sly, PD; Mueller, JF, Monthly variation in faeces: Blood concentration ratio of persistent organic pollutants over the first year of life: A case study of one infant, Environmental Research, 2016, 147, pp. 259-268
gro.hasfulltextNo Full Text
gro.griffith.authorWeijs, Liesbeth

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