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  • IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection

    Author(s)
    Sebina, I
    Fogg, LG
    James, KR
    Soon, MSF
    Akter, J
    Thomas, BS
    Hill, GR
    Engwerda, CR
    Haque, A
    Griffith University Author(s)
    Engwerda, Christian R.
    Year published
    2017
    Metadata
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    Abstract
    Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4+ T cells, B cells, interleukin (IL)-21 and ICOS. IL-6, a cytokine readily detected in Plasmodium-infected mice and humans, is recognized in other systems as a driver of humoral immunity. Here, we examined the effect of infection-induced IL-6 on humoral immunity to Plasmodium. Using P. chabaudi chabaudi AS (PcAS) infection of wild-type and IL-6−/− ...
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    Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4+ T cells, B cells, interleukin (IL)-21 and ICOS. IL-6, a cytokine readily detected in Plasmodium-infected mice and humans, is recognized in other systems as a driver of humoral immunity. Here, we examined the effect of infection-induced IL-6 on humoral immunity to Plasmodium. Using P. chabaudi chabaudi AS (PcAS) infection of wild-type and IL-6−/− mice, we found that IL-6 helped to control parasites during primary infection. IL-6 promoted early production of parasite-specific IgM but not IgG. Notably, splenic CD138+ plasmablast development was more dependent on IL-6 than germinal centre (GC) B-cell differentiation. IL-6 also promoted ICOS expression by CD4+ T cells, as well as their localization close to splenic B cells, but was not required for early Tfh-cell development. Finally, IL-6 promoted parasite control, IgM and IgG production, GC B-cell development and ICOS expression by Tfh cells in a second model, Py17XNL infection. IL-6 promotes CD4+ T-cell activation and B-cell responses during blood-stage Plasmodium infection, which encourages parasite-specific antibody production.
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    Journal Title
    Parasite Immunology
    Volume
    39
    Issue
    10
    DOI
    https://doi.org/10.1111/pim.12455
    Subject
    Microbiology
    Veterinary sciences
    Medical microbiology
    Science & Technology
    Life Sciences & Biomedicine
    Immunology
    Parasitology
    animal model
    Publication URI
    http://hdl.handle.net/10072/408956
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