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  • The toxicity of Aloe barbadensis Miller juice is due to the induction of oxidative stress

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    70037_1.pdf (253.9Kb)
    Author(s)
    Cock, Ian
    P, Joseph
    Griffith University Author(s)
    Cock, Ian E.
    P, Joseph S.
    Year published
    2011
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    Abstract
    Exposure of Artemia nauplii to Aloe vera juice resulted in acute toxicity at dilutions as low as approximately 4 % (24 h LC50 4.6 % ᠰ.3). All antioxidants examined were also toxic when tested in high doses with 24 h LC50's in the following order of toxicity: vitamin C (203.1 姯ml ᠱ1.3) > Trolox頨283.3姯ml ᠲ5.8) > vitamin E (only low toxicity was observed at 24 h). At lower doses, vitamin E and Trolox頷ere non-toxic and could block the toxicity induced by Aloe vera juice. Vitamin E was more effective than Trolox鮠Treatment of A. franciscana with antioxidants prior to exposure to juice was more effective than the simultaneous ...
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    Exposure of Artemia nauplii to Aloe vera juice resulted in acute toxicity at dilutions as low as approximately 4 % (24 h LC50 4.6 % ᠰ.3). All antioxidants examined were also toxic when tested in high doses with 24 h LC50's in the following order of toxicity: vitamin C (203.1 姯ml ᠱ1.3) > Trolox頨283.3姯ml ᠲ5.8) > vitamin E (only low toxicity was observed at 24 h). At lower doses, vitamin E and Trolox頷ere non-toxic and could block the toxicity induced by Aloe vera juice. Vitamin E was more effective than Trolox鮠Treatment of A. franciscana with antioxidants prior to exposure to juice was more effective than the simultaneous treatment of antioxidant and the toxin, suggesting that Aloe vera juice induced lethality is due to oxidative stress which can be blocked by antioxidant addition. The mechanism of Aloe vera juice toxicity was examined by measuring its effect on various biomarker enzymes. Exposure of Artemia nauplii to sub-lethal levels of Aloe vera juice resulted in a decreased activity of thioredoxin reductase, glutathione reductase and glutathione peroxidase by 34%, 79% and 90% respectively. Vitamin E co-exposure resulted in enzyme activities closer to the control value (78%, 56% and 32% of control enzymatic activities for thioredoxin reductase, glutathione reductase and glutathione peroxidase activity respectively). These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that vitamin E addition helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
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    Journal Title
    Advances in Environmental Biology
    Volume
    5
    Issue
    2
    Publisher URI
    http://www.aensionline.com/aeb/2011/288-299.pdf
    Copyright Statement
    © 2011 American-Eurasian Network for Scientific Information. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological Sciences not elsewhere classified
    Environmental Science and Management
    Publication URI
    http://hdl.handle.net/10072/40900
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    • Journal articles

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