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dc.contributor.authorCock, Ianen_US
dc.contributor.authorP, Josephen_US
dc.date.accessioned2017-05-03T11:29:05Z
dc.date.available2017-05-03T11:29:05Z
dc.date.issued2011en_US
dc.date.modified2011-09-22T06:49:30Z
dc.identifier.issn19950756en_US
dc.identifier.urihttp://hdl.handle.net/10072/40900
dc.description.abstractExposure of Artemia nauplii to Aloe vera juice resulted in acute toxicity at dilutions as low as approximately 4 % (24 h LC50 4.6 % ᠰ.3). All antioxidants examined were also toxic when tested in high doses with 24 h LC50's in the following order of toxicity: vitamin C (203.1 姯ml ᠱ1.3) > Trolox頨283.3姯ml ᠲ5.8) > vitamin E (only low toxicity was observed at 24 h). At lower doses, vitamin E and Trolox頷ere non-toxic and could block the toxicity induced by Aloe vera juice. Vitamin E was more effective than Trolox鮠Treatment of A. franciscana with antioxidants prior to exposure to juice was more effective than the simultaneous treatment of antioxidant and the toxin, suggesting that Aloe vera juice induced lethality is due to oxidative stress which can be blocked by antioxidant addition. The mechanism of Aloe vera juice toxicity was examined by measuring its effect on various biomarker enzymes. Exposure of Artemia nauplii to sub-lethal levels of Aloe vera juice resulted in a decreased activity of thioredoxin reductase, glutathione reductase and glutathione peroxidase by 34%, 79% and 90% respectively. Vitamin E co-exposure resulted in enzyme activities closer to the control value (78%, 56% and 32% of control enzymatic activities for thioredoxin reductase, glutathione reductase and glutathione peroxidase activity respectively). These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that vitamin E addition helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent260010 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican-Eurasian Network for Scientific Informationen_US
dc.publisher.placeJordanen_US
dc.publisher.urihttp://www.aensionline.com/aeb/2011/288-299.pdfen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom288en_US
dc.relation.ispartofpageto299en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalAdvances in Environmental Biologyen_US
dc.relation.ispartofvolume5en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiological Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode069999en_US
dc.titleThe toxicity of Aloe barbadensis Miller juice is due to the induction of oxidative stressen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.rights.copyright© 2011 American-Eurasian Network for Scientific Information. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorP, Joseph S.


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