Show simple item record

dc.contributor.authorCock, Ian
dc.contributor.authorP, Joseph
dc.date.accessioned2017-05-03T11:29:05Z
dc.date.available2017-05-03T11:29:05Z
dc.date.issued2011
dc.date.modified2011-09-22T06:49:30Z
dc.identifier.issn19950756
dc.identifier.urihttp://hdl.handle.net/10072/40900
dc.description.abstractExposure of Artemia nauplii to Aloe vera juice resulted in acute toxicity at dilutions as low as approximately 4 % (24 h LC50 4.6 % ᠰ.3). All antioxidants examined were also toxic when tested in high doses with 24 h LC50's in the following order of toxicity: vitamin C (203.1 姯ml ᠱ1.3) > Trolox頨283.3姯ml ᠲ5.8) > vitamin E (only low toxicity was observed at 24 h). At lower doses, vitamin E and Trolox頷ere non-toxic and could block the toxicity induced by Aloe vera juice. Vitamin E was more effective than Trolox鮠Treatment of A. franciscana with antioxidants prior to exposure to juice was more effective than the simultaneous treatment of antioxidant and the toxin, suggesting that Aloe vera juice induced lethality is due to oxidative stress which can be blocked by antioxidant addition. The mechanism of Aloe vera juice toxicity was examined by measuring its effect on various biomarker enzymes. Exposure of Artemia nauplii to sub-lethal levels of Aloe vera juice resulted in a decreased activity of thioredoxin reductase, glutathione reductase and glutathione peroxidase by 34%, 79% and 90% respectively. Vitamin E co-exposure resulted in enzyme activities closer to the control value (78%, 56% and 32% of control enzymatic activities for thioredoxin reductase, glutathione reductase and glutathione peroxidase activity respectively). These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that vitamin E addition helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent260010 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican-Eurasian Network for Scientific Information
dc.publisher.placeJordan
dc.publisher.urihttp://www.aensionline.com/aeb/2011/288-299.pdf
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom288
dc.relation.ispartofpageto299
dc.relation.ispartofissue2
dc.relation.ispartofjournalAdvances in Environmental Biology
dc.relation.ispartofvolume5
dc.rights.retentionY
dc.subject.fieldofresearchBiological Sciences not elsewhere classified
dc.subject.fieldofresearchEnvironmental Science and Management
dc.subject.fieldofresearchcode069999
dc.subject.fieldofresearchcode0502
dc.titleThe toxicity of Aloe barbadensis Miller juice is due to the induction of oxidative stress
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2011 American-Eurasian Network for Scientific Information. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorP, Joseph S.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record