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dc.contributor.authorNg, J
dc.contributor.authorLoukogeorgakis, S
dc.contributor.authorSanna, E
dc.contributor.authorDerwig, I
dc.contributor.authorYu, C
dc.contributor.authorParamasivam, G
dc.contributor.authorLees, C
dc.contributor.authorFarrugia, MK
dc.date.accessioned2021-10-14T01:32:47Z
dc.date.available2021-10-14T01:32:47Z
dc.date.issued2021
dc.identifier.issn0378-3782
dc.identifier.doi10.1016/j.earlhumdev.2021.105382
dc.identifier.urihttp://hdl.handle.net/10072/409033
dc.description.abstractBackground: The majority of simple renal cysts diagnosed postnatally are asymptomatic and rarely require treatment unless they become symptomatic or complex. We hypothesised that prenatally-detected simple renal cysts would have a similar harmless outcome. Aims: To establish the natural history and postnatal outcome of prenatally-diagnosed simple renal cysts. Study design: Single-centre retrospective case-series review (12-year period). Subjects: All patients with prenatally-diagnosed simple renal cysts (defined as a solitary, non-septated, non-communicating cyst in an otherwise normal kidney). Outcome measures: Prenatal and postnatal changes to cyst size, persistence, resolution or modification of diagnosis. Data is presented as the proportion of patients or median (range). Results: 30 cysts were detected (2 bilateral, 26 unilateral) in 28 fetuses (median gestational age of 23 [20–36] weeks). Median maximum diameter was 15 (4–35) mm at initial diagnosis and 17.5 (4–100) mm across all prenatal scans. On follow-up scans diagnosis was modified in 16 (53%) to: multicystic dysplastic kidney (MCDK), dilated duplex kidney, hydronephrosis, urinoma, renal agenesis and adrenal mass. 12 (40%) cysts resolved. 2 (7%) asymptomatic cysts persisted at one year postnatally. Cyst maximum diameter in the modified diagnosis group (21.5 [10−100] mm) was significantly larger than the simple cyst group (12 [4–20] mm) (P = 0.03). Conclusions: Our study revealed the challenges of prenatal ultrasound imaging, with modified diagnoses in over half the cases. Kidneys with solitary cysts could evolve into multicystic kidneys or involute completely, which suggests a true alteration in morphology rather than sonographic error. Persistent simple cysts in an otherwise normal kidney, however, resolved spontaneously or remained asymptomatic. Prenatally-detected simple cysts should be monitored with serial imaging.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom105382
dc.relation.ispartofjournalEarly Human Development
dc.relation.ispartofvolume157
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchReproductive medicine
dc.subject.fieldofresearchApplied and developmental psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3215
dc.subject.fieldofresearchcode5201
dc.subject.keywordsAntenatal ultrasound
dc.subject.keywordsFetal kidney
dc.subject.keywordsMulticystic dysplastic kidney
dc.subject.keywordsPrenatal diagnosis
dc.subject.keywordsRenal cyst
dc.titlePostnatal outcome of prenatally-detected “simple” renal cysts: Are they really simple?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNg, J; Loukogeorgakis, S; Sanna, E; Derwig, I; Yu, C; Paramasivam, G; Lees, C; Farrugia, MK, Postnatal outcome of prenatally-detected “simple” renal cysts: Are they really simple?, Early Human Development, 2021, 157, pp. 105382
dcterms.dateAccepted2021-04-26
dc.date.updated2021-10-11T04:20:51Z
gro.hasfulltextNo Full Text
gro.griffith.authorNg, Jessica Y.


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