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dc.contributor.authorRisal, Prabodh
dc.contributor.authorShrestha, Nirajan
dc.contributor.authorChand, Lokendra
dc.contributor.authorSylvester, Karl G
dc.contributor.authorJeong, Yeon Jun
dc.date.accessioned2021-10-14T04:10:49Z
dc.date.available2021-10-14T04:10:49Z
dc.date.issued2017
dc.identifier.issn0344-0338
dc.identifier.doi10.1016/j.prp.2017.01.005
dc.identifier.urihttp://hdl.handle.net/10072/409060
dc.description.abstractLiver regenerates remarkably after toxic injury or surgical resection. In the case of failure of resident hepatocytes to restore loss, repopulation is carried out by induction, proliferation, and differentiation of the progenitor cell. Although, some signaling pathways have been verified to contribute oval cell-mediated liver regeneration, role of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Pin1) in the oval cells proliferation is unknown. In the present study, we evaluate the role of Pin1 in oval cells proliferation. In our study, the expression of Pin1 in the mice liver increased after three weeks feeding of 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) diet along with the proliferation of oval cells. The expression of Pin1 was higher in oval cells compared to the hepatocytes.Pin1 inhibition by Juglone reduced oval cell proliferation, which was restored to normal when oval cells were treated with IGF-1. Consistent with increased cell growth, expression of Pin1, β-catenin and PCNA were increased in IGF-1 treated cells in a time dependent manner. In FACS analysis, siRNA-mediated knockdown of the Pin1 protein in the oval cells significantly increased the numbers of cells in G0/G1 phase. Furthermore, hepatocyte when treated with TGF-β showed marked reduction in cell proliferation and expression of Pin1 whereas this effect was not seen in the oval cells treated with TGF-β. In conclusion, Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAG
dc.relation.ispartofpagefrom373
dc.relation.ispartofpageto380
dc.relation.ispartofissue4
dc.relation.ispartofjournalPathology - Research and Practice
dc.relation.ispartofvolume213
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPathology
dc.subject.keywords3, 5-Diethoxycarbonyl-1
dc.subject.keywords4-Dihydrocollidine
dc.titleInvolvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRisal, P; Shrestha, N; Chand, L; Sylvester, KG; Jeong, YJ, Involvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells, Pathology - Research and Practice, 2017, 213 (4), pp. 373-380
dcterms.dateAccepted2017-01-06
dc.date.updated2021-10-14T04:09:32Z
gro.hasfulltextNo Full Text
gro.griffith.authorShrestha, Nirajan


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