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dc.contributor.authorNg, Justin Y
dc.contributor.authorReason, Sacha
dc.contributor.authorNg, Jessica Y
dc.date.accessioned2021-10-14T04:50:35Z
dc.date.available2021-10-14T04:50:35Z
dc.date.issued2021
dc.identifier.issn2168-8184en_US
dc.identifier.doi10.7759/cureus.17445en_US
dc.identifier.urihttp://hdl.handle.net/10072/409076
dc.description.abstractPortal vein thrombosis (PVT) is most commonly seen in people with predisposing conditions such as cirrhosis, hepatobiliary malignancies, infectious or inflammatory abdominal disease, or haematologic disorders. However, the incidence of idiopathic portal vein thrombosis in non-cirrhotic people is low and approximately 25% of existing cases have no identifiable cause. If untreated, complications can include portal hypertension, a cavernous transformation of the portal vein, varices, septic thrombosis, or intestinal ischemia. We report the case of a 27-year-old female who presented to her general practitioner with two weeks of epigastric pain. She was referred for an upper abdominal USG and CT imaging, which identified portal vein thrombosis with a normal appearance of the gallbladder, liver, and spleen. Thrombophilia screen was negative for Factor V Leiden and prothrombin mutations and lupus anticoagulant. The tumour markers alpha-fetoprotein and carcinoembryonic antigen were also within normal limits. The patient was started on rivaroxaban indefinitely following advice from a vascular surgeon and haematologist. Subsequent follow-up imaging also revealed cavernous transformation of the portal vein. We present this case to discuss the diagnosis, management and treatment of this patient and to review the current evidence available in managing idiopathic portal vein thrombosis in non-cirrhotic patients, especially the role of anticoagulation in chronic cases.en_US
dc.description.peerreviewedYesen_US
dc.languageenen_US
dc.publisherCureus, Inc.en_US
dc.relation.ispartofpagefrome17445en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalCureusen_US
dc.relation.ispartofvolume13en_US
dc.subject.fieldofresearchClinical sciencesen_US
dc.subject.fieldofresearchcode3202en_US
dc.titleIdiopathic Portal Vein Thrombosis in a Non-cirrhotic Patient: A Discussion of Management and a Review of Literatureen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationNg, JY; Reason, S; Ng, JY, Idiopathic Portal Vein Thrombosis in a Non-cirrhotic Patient: A Discussion of Management and a Review of Literature, Cureus, 2021, 13 (8), pp. e17445en_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-10-12T04:40:11Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2021 Ng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
gro.hasfulltextFull Text
gro.griffith.authorNg, Jessica Y.


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