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  • Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

    Author(s)
    Begley, C Glenn
    Ashton, Mark
    Baell, Jonathan
    Bettess, Michael
    Brown, Michael P
    Carter, Brett
    Charman, William N
    Davis, Christopher
    Fisher, Simon
    Frazer, Ian
    Gautam, Anand
    Jennings, Michael P
    Kearney, Philip
    Keeffe, Eloise
    et al.
    Griffith University Author(s)
    Jennings, Michael P.
    Year published
    2021
    Metadata
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    Abstract
    Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that a repurposed drug can be used for a new indication. This may explain the inability of drug repurposing to fulfill its promise. Important aspects, often overlooked, include financial and intellectual property considerations, the clinical and regulatory path, and clinical equipoise, which provides ethical justification for randomized controlled trials. The goal of drug repurposing is to obtain a new regulator-approved ...
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    Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that a repurposed drug can be used for a new indication. This may explain the inability of drug repurposing to fulfill its promise. Important aspects, often overlooked, include financial and intellectual property considerations, the clinical and regulatory path, and clinical equipoise, which provides ethical justification for randomized controlled trials. The goal of drug repurposing is to obtain a new regulator-approved label for an existing drug, and so, the trajectory for drug repurposing and traditional drug development is similar. Here, we discuss factors critical for a successful repurposed medicine to help academic investigators better identify drug repurposing opportunities.
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    Journal Title
    Science Translational Medicine
    Volume
    13
    Issue
    612
    DOI
    https://doi.org/10.1126/scitranslmed.abd5524
    Subject
    Pharmacology and pharmaceutical sciences
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Cell Biology
    Medicine, Research & Experimental
    Research & Experimental Medicine
    Publication URI
    http://hdl.handle.net/10072/409102
    Collection
    • Journal articles

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