Show simple item record

dc.contributor.authorKeane, J
dc.contributor.authorYoung, N
dc.contributor.authorGoh, J
dc.contributor.authorAtherton, M
dc.contributor.authorYin, J
dc.contributor.authorMoore, K
dc.contributor.authorHall, P
dc.contributor.authorHiggs, P
dc.contributor.authorLeitch, A
dc.contributor.authorLee, J
dc.contributor.authorRosamilia, A
dc.date.accessioned2021-10-15T05:47:29Z
dc.date.available2021-10-15T05:47:29Z
dc.date.issued2021
dc.identifier.issn0301-2115
dc.identifier.doi10.1016/j.ejogrb.2020.10.060
dc.identifier.urihttp://hdl.handle.net/10072/409106
dc.description.abstractObjective: Bladder pain syndrome (BPS) is a chronic pain condition associated with injury to the glycosoaminoglycan (GAG) layer. We aimed to prospectively evaluate iAluRil® with multi-centre tertiary urogynaecology collaboration. We hypothesised that iAluRil® (a GAG therapy) would demonstrate equivalent symptom, pain and QOL scores compared to DMSO controls. Study Design: iAluRil® was administered for 7 instillations over 3 months in 34 women over 6 sites. 18 historical DMSO controls were matched 2:1. At baseline and 3 months post treatment validated questionnaires were collected. Results: Both iAluRil® and DMSO were associated with statistically significant improvements in IC/BPS specific questionnaire scores. iAluRil® showed statistically significant improvements in pain, symptoms, and QOL. 45 % of iAluRil® recipients had a greater than 50 % reduction in pain score as represented by the VAS. DMSO was also effective in improving measures of IC/BPS with statistically significant decreases in ICSI and ICPI. There was no statistically significant difference in the size of the effect between DMSO and IAluRil®. Conclusions: iAluRil® is well tolerated and associated with significant improvements in pain and symptom scores. Almost half of refractory BPS will have a 50 % decrease in pain score at three months post treatment. This effect size is similar to DMSO.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom230
dc.relation.ispartofpageto234
dc.relation.ispartofjournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
dc.relation.ispartofvolume256
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchReproductive medicine
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3215
dc.subject.keywordsBladder pain syndrome
dc.subject.keywordsDMSO
dc.subject.keywordsInterstitial cystitis
dc.subject.keywordsOveractive bladder
dc.subject.keywordsiAluRil®
dc.titleA comparison of two intravesical bladder instillations for interstitial cystitis/bladder pain syndrome
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKeane, J; Young, N; Goh, J; Atherton, M; Yin, J; Moore, K; Hall, P; Higgs, P; Leitch, A; Lee, J; Rosamilia, A, A comparison of two intravesical bladder instillations for interstitial cystitis/bladder pain syndrome, European Journal of Obstetrics and Gynecology and Reproductive Biology, 2021, 256, pp. 230-234
dcterms.dateAccepted2020-10-23
dc.date.updated2021-10-15T05:46:22Z
gro.hasfulltextNo Full Text
gro.griffith.authorGoh, Judith T.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record