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dc.contributor.authorWaugh, Courtney A.en_US
dc.contributor.authorHuston, Wilhelmina M.en_US
dc.contributor.authorNoad, Michael J.en_US
dc.contributor.authorBengtson Nash, Susanen_US
dc.date.accessioned2018-12-12T01:31:53Z
dc.date.available2018-12-12T01:31:53Z
dc.date.issued2011en_US
dc.date.modified2011-09-22T06:50:11Z
dc.identifier.issn0025326Xen_US
dc.identifier.doi10.1016/j.marpolbul.2011.01.007en_US
dc.identifier.urihttp://hdl.handle.net/10072/40912
dc.description.abstractLarge mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptions. Molecular biomarkers offer the potential to complement information yielded through tissue chemical analysis, as well as providing evidence of a molecular response to chemical exposure. In this study we confirm the presence of cytochrome P450 reductase (CPR) and cytochrome P450 isoenzyme 1A1 (CYP1A1) in epidermal tissue of southern hemisphere humpback whales (Megaptera novaeangliae). The detection of CYP1A1 in the integument of the humpback whale affords the opportunity for further quantitative non-destructive investigations of enzyme activity as a function of chemical stress.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationYen_AU
dc.relation.ispartofpagefrom758en_US
dc.relation.ispartofpageto761en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalMarine Pollution Bulletinen_US
dc.relation.ispartofvolume62en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchEnvironmental Science and Management not elsewhere classifieden_US
dc.subject.fieldofresearchcode050299en_US
dc.titleCytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessmenten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.description.versionPost-printen_US
gro.rights.copyright© 2011 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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