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dc.contributor.authorWaugh, Courtney A
dc.contributor.authorHuston, Wilhelmina M
dc.contributor.authorNoad, Michael J
dc.contributor.authorNash, Susan Bengtson
dc.date.accessioned2018-12-12T01:31:53Z
dc.date.available2018-12-12T01:31:53Z
dc.date.issued2011
dc.date.modified2011-09-22T06:50:11Z
dc.identifier.issn0025-326X
dc.identifier.doi10.1016/j.marpolbul.2011.01.007
dc.identifier.urihttp://hdl.handle.net/10072/40912
dc.description.abstractLarge mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptions. Molecular biomarkers offer the potential to complement information yielded through tissue chemical analysis, as well as providing evidence of a molecular response to chemical exposure. In this study we confirm the presence of cytochrome P450 reductase (CPR) and cytochrome P450 isoenzyme 1A1 (CYP1A1) in epidermal tissue of southern hemisphere humpback whales (Megaptera novaeangliae). The detection of CYP1A1 in the integument of the humpback whale affords the opportunity for further quantitative non-destructive investigations of enzyme activity as a function of chemical stress.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom758
dc.relation.ispartofpageto761
dc.relation.ispartofissue4
dc.relation.ispartofjournalMarine Pollution Bulletin
dc.relation.ispartofvolume62
dc.rights.retentionY
dc.subject.fieldofresearchEnvironmental Science and Management not elsewhere classified
dc.subject.fieldofresearchcode050299
dc.titleCytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionPost-print
gro.rights.copyright© 2011 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorBengtson Nash, Susan


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