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  • Novel cytotoxic constituents of Orthosiphon diffusus

    Author(s)
    Holla, Harish
    Srinivas, Yallamalla
    Majhi, Anjoy
    Srinivasulu, Gannoju
    Sridhar, Balasubramanian
    Krishna, Arepalli Sai
    Rao, Janapala Venkateswara
    Das, Biswanath
    Griffith University Author(s)
    Holla Venkataraman, Harish
    Year published
    2011
    Metadata
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    Abstract
    Chemical investigation on Orthosiphon diffusus resulted in the isolation of four relatively rare, novel polychiral furanopyrans, orthodiffenes A-D (1-4) which were characterized from detailed studies of their 1D and 2D NMR spectra. The X-ray crystallographic analysis of orthodiffene A (1) was accomplished. The in vitro cytotoxic activity of orthodiffenes A-C (1-3) was tested against Jurkat and HL-60 cells using camptothecin as a positive control. Orthodiffenes A (1) and B (2) showed comparable activity to camptothecin against HL-60 and Jurkat cells, respectively.Chemical investigation on Orthosiphon diffusus resulted in the isolation of four relatively rare, novel polychiral furanopyrans, orthodiffenes A-D (1-4) which were characterized from detailed studies of their 1D and 2D NMR spectra. The X-ray crystallographic analysis of orthodiffene A (1) was accomplished. The in vitro cytotoxic activity of orthodiffenes A-C (1-3) was tested against Jurkat and HL-60 cells using camptothecin as a positive control. Orthodiffenes A (1) and B (2) showed comparable activity to camptothecin against HL-60 and Jurkat cells, respectively.
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    Journal Title
    Tetrahedron Letters
    Volume
    52
    Issue
    1
    DOI
    https://doi.org/10.1016/j.tetlet.2010.10.140
    Subject
    Natural Products Chemistry
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Publication URI
    http://hdl.handle.net/10072/40917
    Collection
    • Journal articles

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