Novel cytotoxic constituents of Orthosiphon diffusus
Author(s)
Holla, Harish
Srinivas, Yallamalla
Majhi, Anjoy
Srinivasulu, Gannoju
Sridhar, Balasubramanian
Krishna, Arepalli Sai
Rao, Janapala Venkateswara
Das, Biswanath
Griffith University Author(s)
Year published
2011
Metadata
Show full item recordAbstract
Chemical investigation on Orthosiphon diffusus resulted in the isolation of four relatively rare, novel polychiral furanopyrans, orthodiffenes A-D (1-4) which were characterized from detailed studies of their 1D and 2D NMR spectra. The X-ray crystallographic analysis of orthodiffene A (1) was accomplished. The in vitro cytotoxic activity of orthodiffenes A-C (1-3) was tested against Jurkat and HL-60 cells using camptothecin as a positive control. Orthodiffenes A (1) and B (2) showed comparable activity to camptothecin against HL-60 and Jurkat cells, respectively.Chemical investigation on Orthosiphon diffusus resulted in the isolation of four relatively rare, novel polychiral furanopyrans, orthodiffenes A-D (1-4) which were characterized from detailed studies of their 1D and 2D NMR spectra. The X-ray crystallographic analysis of orthodiffene A (1) was accomplished. The in vitro cytotoxic activity of orthodiffenes A-C (1-3) was tested against Jurkat and HL-60 cells using camptothecin as a positive control. Orthodiffenes A (1) and B (2) showed comparable activity to camptothecin against HL-60 and Jurkat cells, respectively.
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Journal Title
Tetrahedron Letters
Volume
52
Issue
1
Subject
Natural Products Chemistry
Medicinal and Biomolecular Chemistry
Organic Chemistry