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dc.contributor.authorPellatt, Richard AF
dc.contributor.authorKamona, Sinan
dc.contributor.authorChu, Kevin
dc.contributor.authorSweeny, Amy
dc.contributor.authorKuan, Win Sen
dc.contributor.authorKinnear, Frances B
dc.contributor.authorKaramercan, Mehmet A
dc.contributor.authorKlim, Sharon
dc.contributor.authorWijeratne, Tissa
dc.contributor.authorGraham, Colin A
dc.contributor.authorBody, Richard
dc.contributor.authorRoberts, Tom
dc.contributor.authorHorner, Daniel
dc.contributor.authorKeijzers, Gerben
dc.contributor.authoret al.
dc.description.abstractOBJECTIVE: To describe the patterns of opioid use in patients presenting to the emergency department (ED) with nontraumatic headache by severity and geography. BACKGROUND: International guidelines recognize opioids are ineffective in treating primary headache disorders. Globally, many countries are experiencing an opioid crisis. The ED can be a point of initial exposure leading to tolerance for patients. More geographically diverse data are required to inform practice. METHODS: This was a planned, multicenter, cross-sectional, observational substudy of the international Headache in Emergency Departments (HEAD) study. Participants were prospectively identified throughout March 2019 from 67 hospitals in Europe, Asia, Australia, and New Zealand. Adult patients with nontraumatic headache were included as identified by the local site investigator. RESULTS: Overall, 4536 patients were enrolled in the HEAD study. Opioids were administered in 1072/4536 (23.6%) patients in the ED, and 386/3792 (10.2%) of discharged patients. High opioid use occurred prehospital in Australia (190/1777, 10.7%) and New Zealand (55/593, 9.3%). Opioid use in the ED was highest in these countries (Australia: 586/1777, 33.0%; New Zealand: 221/593, 37.3%). Opioid prescription on discharge was highest in Singapore (125/442, 28.3%) and Hong Kong (12/49, 24.5%). Independent predictors of ED opioid administration included the following: severe headache (OR 4.2, 95% CI 3.1-5.5), pre-ED opioid use (OR 1.42, 95% CI 1.11-1.82), and long-term opioid use (OR 1.80, 95% CI 1.26-2.58). ED opioid administration independently predicted opioid prescription at discharge (OR 8.4, 95% CI 6.3-11.0). CONCLUSION: Opioid prescription for nontraumatic headache in the ED and on discharge varies internationally. Severe headache, prehospital opioid use, and long-term opioid use predicted ED opioid administration. ED opioid administration was a strong predictor of opioid prescription at discharge. These findings support education around policy and guidelines to ensure adherence to evidence-based interventions for headache.
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchEmergency medicine
dc.subject.keywordsprimary headache disorder
dc.titleThe Headache in Emergency Departments study: Opioid prescribing in patients presenting with headache. A multicenter, cross-sectional, observational study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPellatt, RAF; Kamona, S; Chu, K; Sweeny, A; Kuan, WS; Kinnear, FB; Karamercan, MA; Klim, S; Wijeratne, T; Graham, CA; Body, R; Roberts, T; Horner, D; Keijzers, G; et al., The Headache in Emergency Departments study: Opioid prescribing in patients presenting with headache. A multicenter, cross-sectional, observational study, Headache, 2021
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.hasfulltextNo Full Text
gro.griffith.authorKeijzers, Gerben
gro.griffith.authorPellatt, Richard A.
gro.griffith.authorSweeny, Amy L.

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