Show simple item record

dc.contributor.authorRashid, Muhammed
dc.contributor.authorChandran, Viji Pulikkel
dc.contributor.authorNair, Sreedharan
dc.contributor.authorMuthu, Deepa Sudalai
dc.contributor.authorPappuraj, Jemima
dc.contributor.authorJacob, Krupa Ann
dc.contributor.authorSridhar, Balaji
dc.contributor.authorMark, Karen
dc.contributor.authorHyder, Shabnam
dc.contributor.authorKhan, Sohil
dc.contributor.authorThunga, Girish
dc.description.abstractBackground: Treatment with N-Acetyl Cysteine (NAC) in rodenticide poisoning has not been well established due to mixed study results and insufficient evidence. This review aimed to summarize the clinical benefits of NAC in the management of rodenticide poisoning. Methods: This review follows the PICOS framework and the PRISMA guidelines. Pub- Med/MEDLINE, Scopus, and the Cochrane library were searched to identify the published literature from inception to September 2020, and a reference search was performed for additional relevant studies. The English language studies addressing the use of NAC in rodenticide poisoning were considered for the review. We considered all experimental and observational studies due to the insufficient number of interventional studies. Results: Ten studies (two RCTs, four observational, and four descriptive) out of 2,178 studies with 492 participants were considered for the review. Only six studies (two RCTs, one prospective, and three retrospective studies) reported recovery and mortality. Pooled results of RCTs (n=2) showed a significant recovery rate (Odds Ratio [OR]: 3.97; 95% Confidence Interval [CI]:1.69-9.30), whereas summary estimates of prospective and retrospective studies recorded a non-significant effect. Metaanalysis of RCTs (OR: 0.25; 95% CI: 0.11-0.59; n=2) and retrospective studies (OR: 0.34; 95% CI: 0.15-0.78; n=3) showed a significant reduction in mortality, whereas pooled analysis of prospective studies recorded a non-significant effect. A significant reduction in intubation or ventilation (OR: 0.25; 95% CI: 0.11-0.60; 2 RCTs) and a non-significant (P=0.41) difference in duration of hospitalization was observed with NAC when compared to the non-NAC treated group. The quality of the included studies appeared to be moderate to high. Conclusion: Our findings indicate that NAC showed better survival and lower mortality rate when compared to non-NAC treated group; hence NAC can be considered for the management of rodenticide poisoning. PROSPERO registration number: CRD42020154376.
dc.publisherBentham Science Publishers Ltd.
dc.relation.ispartofjournalCurrent Reviews in Clinical and Experimental Pharmacology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.titleN-Acetyl cysteine in rodenticide poisoning: A systematic review and meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRashid, M; Chandran, VP; Nair, S; Muthu, DS; Pappuraj, J; Jacob, KA; Sridhar, B; Mark, K; Hyder, S; Khan, S; Thunga, G, N-Acetyl cysteine in rodenticide poisoning: A systematic review and meta-analysis, Current Reviews in Clinical and Experimental Pharmacology, 2021
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorKhan, Sohil A.

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record